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Interim PET/CT in diffuse large B-cell lymphoma may facilitate identification of good-prognosis patients among IPI-stratified patients
- Source :
- International Journal of Hematology. 110:331-339
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Treating patients with DLBCL remains a challenge, as the response to first-line immunochemotherapy is somewhat unpredictable. The International Prognostic Index (IPI) is one of the most widely used methods for assessing prognosis. Interim PET/CT (iPET/CT) can play an important role in the early identification of 'non-responder' patients before the end of treatment examination. In this study, we retrospectively analyzed 104 newly diagnosed DLBCL patients treated with R-CHOP-like regimens who underwent iPET/CT imaging during therapy. There was a significant difference in 2-year OS between patients with negative iPET/CT and those with positive iPET/CT. Patients who had positive iPET/CT showed inferior 2-year PFS compared to those with negative iPET/CT. According to IPI, there was a statistically significant difference in 2-year OS and PFS between patients in the lower and higher risk groups. However, these patients can be further subdivided according to iPET/CT. The iPET/CT results in the present study clearly separate good- and poor-prognosis patients according to differences in 2-year OS, both in the lower and higher IPI risk groups. These results are in agreement with those of previous studies that demonstrated that iPET/CT has high negative predictive value, clearly identifying good-prognosis patients even within the poor-prognosis IPI group.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
International Prognostic Index
Interim pet ct
Positron Emission Tomography Computed Tomography
hemic and lymphatic diseases
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Cyclophosphamide
Aged
Retrospective Studies
Aged, 80 and over
PET-CT
Hematology
business.industry
Significant difference
Middle Aged
medicine.disease
Interim pet
Survival Rate
Doxorubicin
Vincristine
030220 oncology & carcinogenesis
Prednisone
Female
Lymphoma, Large B-Cell, Diffuse
Good prognosis
Radiology
Rituximab
business
Diffuse large B-cell lymphoma
Follow-Up Studies
030215 immunology
Subjects
Details
- ISSN :
- 18653774 and 09255710
- Volume :
- 110
- Database :
- OpenAIRE
- Journal :
- International Journal of Hematology
- Accession number :
- edsair.doi.dedup.....fde20d2218cb0c633148378fa7773889