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How Do Local Reactivity Descriptors Shape the Potential Energy Surface Associated with Chemical Reactions? The Valence Bond Delocalization Perspective
- Source :
- Journal of the American Chemical Society
- Publication Year :
- 2020
- Publisher :
- American Chemical Society, 2020.
-
Abstract
- How do local reactivity descriptors, such as the Fukui function and the local spin density distribution, shape the potential energy surface (PES) associated with chemical reactions and thus govern reactivity trends and regioselective preferences? This is the question that is addressed here through a qualitative valence bond (VB) analysis. We demonstrate that common density functional theory (DFT)-based local reactivity descriptors can essentially be regarded-in one way or another-as indirect measures of delocalization, i.e., resonance stabilization, of the reactants within VB theory. The inherent connection between (spatial) delocalization and (energetic) resonance stabilization embedded in VB theory provides a natural and elegant framework for analyzing and comprehending the impact of individual local reactivity descriptors on the global PES. Our analysis provides new insights into the role played by local reactivity descriptors and illustrates under which conditions they can sometimes fail to predict reactivity trends and regioselective preferences, e.g., in the case of ambident reactivity. This treatment constitutes a first step toward a unification of VB theory and conceptual DFT.
- Subjects :
- Chemistry
Perspective (graphical)
General Chemistry
010402 general chemistry
01 natural sciences
Biochemistry
Chemical reaction
Catalysis
Article
Addition/Correction
0104 chemical sciences
Delocalized electron
Colloid and Surface Chemistry
Chemical physics
Potential energy surface
Valence bond theory
Density functional theory
Reactivity (chemistry)
Fukui function
Subjects
Details
- Language :
- English
- ISSN :
- 15205126 and 00027863
- Volume :
- 142
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Journal of the American Chemical Society
- Accession number :
- edsair.doi.dedup.....fdda790d8ceced29d636578304383f97