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Evaluation of the major histocompatibility complex (MHC) class II as a candidate for sudden acquired retinal degeneration syndrome (SARDS) in Dachshunds
- Source :
- Veterinary ophthalmology, vol 22, iss 6, Veterinary Ophthalmology
- Publication Year :
- 2019
- Publisher :
- eScholarship, University of California, 2019.
-
Abstract
- Author(s): Stromberg, Stephanie J; Thomasy, Sara M; Marangakis, Ariana D; Kim, Soohyun; Cooper, Ann E; Brown, Emily A; Maggs, David J; Bannasch, Danika L | Abstract: ObjectiveSudden acquired retinal degeneration syndrome (SARDS) is one of the leading causes of acute blindness in dogs, with an unknown etiology and no effective treatment. Certain breeds such as Dachshunds are overrepresented among SARDS patients, and therefore, the syndrome is suspected to have a genetic component. The objective of this study was to determine if a genetic locus associated with SARDS in Dachshunds could be identified using a genome-wide association study (GWAS).ProceduresGenome-wide association mapping was performed in 15 SARDS-affected and 16 unaffected Dachshunds. Genotyping of three classical DLA class II genes (DLA-DRB1, DLA-DQA1, and DLA-DQB1) was performed in 34 SARDS-affected and 66 unaffected Dachshunds to evaluate for an association in this region.ResultsAlthough no single nucleotide polymorphisms (SNPs) were of genome-wide statistical significance (PBonferroni nln0.05), 5 of the top 9 SNPs were in the major histocompatibility complex (MHC). Using DLA typing, the allele DLA-DRB1*09401 was identified as a risk factor for the development of SARDS (Pn=n0.0032, ORn=n4.0). The alleles DLA-DQB1*00101 (Pn=n0.0050, ORn=n0.31), DLA-DQA1*00901 (Pn=n0.0087, ORn=n0.33), and a previously identified DLA-DRB1allele described as "DRB1-T" (Pn=n0.0284, ORn=n0.37) were identified as protective factors.ConclusionsAlthough far from definitive, association of SARDS with alleles of immunologic importance further supports the hypothesis that autoimmunity may play a role in the pathogenesis of SARDS.
- Subjects :
- 040301 veterinary sciences
Single-nucleotide polymorphism
Genome-wide association study
Major histocompatibility complex
genome‐wide association studies
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Dogs
Genetics
Original Report
Medicine
Animals
2.1 Biological and endogenous factors
Genetic Predisposition to Disease
Dog Diseases
Veterinary Sciences
Allele
Aetiology
Association mapping
Genotyping
Eye Disease and Disorders of Vision
General Veterinary
biology
business.industry
Dog leukocyte antigen
Prevention
Retinal Degeneration
Human Genome
Histocompatibility Antigens Class II
sudden acquired retinal degeneration syndrome
Original Articles
04 agricultural and veterinary sciences
3. Good health
dog leukocyte antigen
Dachshund
DLA
genome-wide association studies
030221 ophthalmology & optometry
biology.protein
Sudden acquired retinal degeneration
MHC
business
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Veterinary ophthalmology, vol 22, iss 6, Veterinary Ophthalmology
- Accession number :
- edsair.doi.dedup.....fdd58c92561ab23db98e1e79996ecbc4