Back to Search
Start Over
Combretum leprosum Mart. (Combretaceae): Potential as an antiproliferative and anti-inflammatory agent
- Source :
- Journal of Ethnopharmacology. 145:311-319
- Publication Year :
- 2013
- Publisher :
- Elsevier BV, 2013.
-
Abstract
- Ethnopharmacological relevance Combretum leprosum is a species that is popularly used in Brazil as a healing agent to treat skin problems and lesions. In this study we investigated the possible potential of this extract to treat inflammatory and hyperproliferative skin conditions. Materials and methods Classical models of skin inflammation such as TPA- and croton oil-induced mouse ear oedema were applied in order to verify the potential topical anti-inflammatory activity of the ethanolic extract from flowers of Combretum leprosum . Results Topical application of ethanolic extract promoted a dose-dependent inhibition of phorbol ester-induced ear oedema, reduced myeloperoxidase activity and IL-6 tissue levels with inhibition comparable to dexamethasone (positive control). Histological and immunohistochemical analysis revealed that ethanolic extract also suppressed cell infiltration. Ethanolic extract altered inflammatory parameters on a chronic skin inflammation model induced by repeated applications of croton oil, decreasing ear oedema, epidermal hyperproliferation and cell infiltration. In addition, immunohistochemical analysis showed that the extract decreased PCNA expression on the epidermis. Conclusion Taken together, these results suggest that the extract from flowers of Combretum leprosum could be considered as a new potential tool for the treatment of several skin inflammatory diseases since it reversed the skin inflammatory and hyperproliferative process in a very significant manner. Further investigations are needed in order to verify the cellular mechanism and safety of Combretum leprosum extract.
- Subjects :
- Croton Oil
Anti-Inflammatory Agents
Combretum
Dermatitis, Contact
Combretum leprosum
law.invention
Mice
chemistry.chemical_compound
law
Drug Discovery
Edema
Croton oil
Skin
Arachidonic Acid
integumentary system
biology
Traditional medicine
Ear
Skin diseases
Tetradecanoylphorbol Acetate
Female
medicine.drug
medicine.drug_class
Flowers
Anti-inflammatory
Cell Line
Combretaceae
Proliferating Cell Nuclear Antigen
Acetylglucosaminidase
medicine
Animals
Dexamethasone
Cell Proliferation
Peroxidase
Inflammation
Pharmacology
Dose-Response Relationship, Drug
Ethanol
Interleukin-6
Plant Extracts
business.industry
biology.organism_classification
Croton
Disease Models, Animal
chemistry
Phorbol
Phytotherapy
business
Subjects
Details
- ISSN :
- 03788741
- Volume :
- 145
- Database :
- OpenAIRE
- Journal :
- Journal of Ethnopharmacology
- Accession number :
- edsair.doi.dedup.....fdc9c45b2a4c2d26cd5f979e16ea4c7d