Back to Search
Start Over
Mitochondrial Etiology of Neuropsychiatric Disorders
- Publication Year :
- 2017
-
Abstract
- The brain has the highest mitochondrial energy demand of any organ. Therefore, subtle changes in mitochondrial energy production will preferentially affect the brain. Considerable biochemical evidence has accumulated revealing mitochondrial defects associated with neuropsychiatric diseases. Moreover, the mitochondrial genome encompasses over a thousand nuclear DNA (nDNA) genes plus hundreds to thousands of copies of the maternally-inherited mitochondrial DNA (mtDNA). Therefore, partial defects in either the nDNA or mtDNA genes or combinations of the two can be sufficient to cause neuropsychiatric disorders. Inherited and acquired mtDNA mutations have recently been associated with autism spectrum disorders (ASD), which parallel previous evidence of mtDNA variation in other neurological diseases. Therefore, mitochondrial dysfunction may be central to the etiology of a wide spectrum of neurological diseases. The mitochondria and the nucleus communicate to coordinate energy production and utilization, providing the potential for therapeutics by manipulating nuclear regulation of mitochondrial gene expression.
- Subjects :
- 0301 basic medicine
Genetics
Mitochondrial DNA
Mitochondrial Diseases
Mental Disorders
Oxidative phosphorylation
Mitochondrion
Biology
medicine.disease
Human mitochondrial genetics
DNA, Mitochondrial
Article
Nuclear DNA
Mitochondria
03 medical and health sciences
030104 developmental biology
mitochondrial fusion
Autism spectrum disorder
Central Nervous System Diseases
medicine
Humans
Marriage
Gene
Biological Psychiatry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fdc83d375b22f0a896ef93980c7ec438