Back to Search
Start Over
The Role of AGE-RAGE Signalling as a Modulator of Gut Permeability in Diabetes
- Source :
- International Journal of Molecular Sciences, Vol 23, Iss 1766, p 1766 (2022)
- Publication Year :
- 2021
-
Abstract
- There is increasing evidence for the role of intestinal permeability as a contributing factor in the pathogenesis of diabetes; however, the molecular mechanisms are poorly understood. Advanced glycation endproducts, of both exogenous and endogenous origin, have been shown to play a role in diabetes pathophysiology, in part by their ligation to the receptor for advanced glycation endproducts (RAGE), leading to a proinflammatory signalling cascade. RAGE signalling has been demonstrated to play a role in the development of intestinal inflammation and permeability in Crohn’s disease and ulcerative colitis. In this review, we explore the role of AGE-RAGE signalling and intestinal permeability and explore whether activation of RAGE on the intestinal epithelium may be a downstream event contributing to the pathogenesis of diabetes complications.
- Subjects :
- Glycation End Products, Advanced
diabetes
intestinal permeability
QH301-705.5
Organic Chemistry
Receptor for Advanced Glycation End Products
General Medicine
Catalysis
Permeability
Computer Science Applications
Inorganic Chemistry
Intestines
Chemistry
receptor for advanced glycation endproducts
Diabetes Mellitus
Animals
Humans
Biology (General)
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
advanced glycation endproducts
Spectroscopy
Signal Transduction
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 23
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....fdbdc49d6ea012717aa6ca702b2cf506