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Penile and Scrotal Swelling: An Underrecognized Presentation of Crohn's Disease
- Source :
- Pediatric Dermatology. 33:172-177
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Background Penile and scrotal swelling can occur as an extraintestinal manifestation of Crohn's disease (CD) and is thought to be an uncommon form of metastatic CD (MCD). Because of the rarity of this manifestation, much is unknown concerning the presentation, treatment, and response to therapy in children with genital MCD. Methods Boys ages 1 to 17 years presenting with genital edema and a confirmed diagnosis or strong suspicion of CD who were evaluated at the Mayo Clinic between 1996 and 2014 were included for review. We sought to characterize the clinical and pathologic features of genital MCD and response to treatment in our cohort of patients. Results Eight patients with genital MCD were identified from our institution (mean age 11.4 yrs, range 7-16 yrs). Seven (88%) patients experienced cutaneous symptoms before a formal diagnosis of CD was made, and two of the seven had no adverse gastrointestinal symptoms at that time. Patients were prescribed an average of 3.4 medications (topical and systemic) for management of their gastrointestinal CD and MCD. Conclusions Penile and scrotal swelling can occur as an extraintestinal manifestation of CD and is thought to be an uncommon form of MCD. In boys, genital swelling typically precedes intestinal CD. Treatment of the underlying CD with systemic medications was most helpful in this series. An evaluation for CD is necessary in all patients presenting with unexplained genital swelling.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
Dermatology
Disease
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Crohn Disease
030225 pediatrics
Edema
Scrotum
Humans
Genital Edema
Medicine
Sex organ
Child
Crohn's disease
business.industry
Infant
medicine.disease
Surgery
medicine.anatomical_structure
Child, Preschool
Pediatrics, Perinatology and Child Health
Cohort
medicine.symptom
business
Penis
Subjects
Details
- ISSN :
- 07368046
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Pediatric Dermatology
- Accession number :
- edsair.doi.dedup.....fda5d3c177f907540be7c1ae4b546c49