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Women with regular menstrual cycles and a poor response to ovarian hyperstimulation for in vitro fertilization exhibit follicular phase characteristics suggestive of ovarian aging
- Source :
- Fertility & Sterility, 78(2), 291-297. Elsevier Inc.
- Publication Year :
- 2002
-
Abstract
- Objective: To investigate whether follicular phase characteristics associated with ovarian aging can be observed in women of normal reproductive age, who had previously shown a poor response to ovarian hyperstimulation for IVF. Design: Observational, prospective study. Setting: Tertiary fertility center. Patient(s): Eleven regularly cycling, ovulatory women, aged 29–40 years who previously presented with fewer than four dominant follicles after ovarian hyperstimulation for IVF. Intervention(s): Frequent serum hormone assessments and transvaginal ultrasound during the follicular phase of a spontaneous, unstimulated cycle. Main Outcome Measure(s): Duration of the follicular phase; serum LH, FSH, E 2 , P, inhibin A, and inhibin B levels; and number of antral follicles observed by ultrasound. Results were compared with the cycle characteristics of a reference population of 38 healthy normo-ovulatory women aged 20–36 years (as published elsewhere). Result(s): Poor responders had significantly fewer antral follicles than controls. Median FSH concentrations were significantly higher compared with controls, but the majority had FSH levels within the normal range. Follicular phase P levels were significantly higher in poor responders. Duration of the follicular phase, E 2 , and inhibin A and inhibin B serum levels did not differ between poor responders and controls. Conclusion(s): Normo-ovulatory regularly cycling women with a previous poor response to ovarian hyperstimulation for IVF show follicular phase characteristics suggestive of ovarian aging.
- Subjects :
- Adult
endocrine system
medicine.drug_class
media_common.quotation_subject
medicine.medical_treatment
Ovary
Fertilization in Vitro
Biology
Andrology
Follicle-stimulating hormone
Ovarian Follicle
Follicular phase
medicine
Humans
Inhibins
Prospective Studies
Ovarian follicle
Menstrual cycle
media_common
In vitro fertilisation
Obstetrics and Gynecology
Antral follicle
female genital diseases and pregnancy complications
medicine.anatomical_structure
Reproductive Medicine
Follicular Phase
Female
Gonadotropin
Follicle Stimulating Hormone
Subjects
Details
- ISSN :
- 00150282
- Volume :
- 78
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Fertility and sterility
- Accession number :
- edsair.doi.dedup.....fda4668e1e29d80c13cffe207b7fdee9