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Oral supplement of six selective amino acids arrest progression renal failure in uremic patients
- Source :
- International Urology and Nephrology. 36:591-598
- Publication Year :
- 2004
- Publisher :
- Springer Science and Business Media LLC, 2004.
-
Abstract
- Certain amino acids such as glycine, L-aspartic acid, L-glutamic acid, L-glutamine, L-histidine and L-arginine taken orally by normal adults or patients with renal failure increase glomerular filtration rate (GFR). Twelve nondiabetic patients suffering from glomerulonephritis confirmed by renal biopsy previously, with creatinine clearances ranging from 15 to 24 ml minute/1.73, and on low protein diet 0.6 g/kg/day, received an amino acid supplement daily in 2 or 3 doses for 1 year. At 4, 8 and 12 months creatinine clearance increased slightly (NS, NS, NS), 24 hour urine volume increased (P ≤ 0.001, 001, 0.001), 24 hour albuminuria decreased (P < 0.001, 0.001, 0.001), serum urea increased (NS, NS, NS) serum albumin increased (NS, 0.05, 0.05), total cholesterol decreased slightly (NS, NS, 0.01), HDL increased slightly (0.05, 0.05, 0.05), LDL decreased (NS, 0.001, 0.001) triglycerides decreased (0.001, 0.001, 0.001), Apo B remained unchanged (NS, NS, NS), ROS/H2O2 decreased (0.001, 0,001, 0.001), Hct increased (NS, 0.01, 0.01) Hb increased (0.05, 0.05, 0.05) and serum phosphate decreased (0.01, 0.01, 0.01). After removal of supplements at the end of the year all parameters remained unchanged. We believe that a large controlled study should be undertaken to confirm these most encouraging findings. © 2004 Kluwer Academic Publishers.
- Subjects :
- Adult
Male
Nephrology
medicine.medical_specialty
Apolipoprotein B
Urology
medicine.medical_treatment
Serum albumin
Administration, Oral
Renal function
chemistry.chemical_compound
Low-protein diet
Internal medicine
medicine
Humans
Amino Acids
Uremia
Creatinine
medicine.diagnostic_test
biology
business.industry
Middle Aged
Endocrinology
chemistry
Dietary Supplements
Disease Progression
Albuminuria
biology.protein
Kidney Failure, Chronic
Female
Renal biopsy
medicine.symptom
business
Subjects
Details
- ISSN :
- 15732584 and 03011623
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- International Urology and Nephrology
- Accession number :
- edsair.doi.dedup.....fd9e45a00a624ce1c80fbcc5c0e52de8