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Exploring utility of genomic epidemiology to trace origins of highly pathogenic influenza A/H7N9 in Guangdong
- Source :
- Virus Evolution, 6(2):veaa097. Oxford University Press, Virus Evolution
- Publication Year :
- 2020
-
Abstract
- The first highly pathogenic (HP) influenza A/H7N9 was reported in Guangdong in January 2017. To investigate the emergence and spread of HP A/H7N9 in Guangdong province, we sequenced 297 viruses (58 HP A/H7N9, 19 low pathogenic (LP) A/H7N9, and 220 A/H9N2) during 2016–2017. Our analysis showed that during the fifth wave, three A/H7N9 lineages were co-circulating in Guangdong: the local LP Pearl River Delta (PRD) lineage (13%), the newly imported LP Yangtze River Delta (YRD) lineage (23%), and the HP YRD lineage (64%). Previously circulating YRD-lineage LP during the third wave evolved to the YRD-lineage HP A/H7N9 in Guangdong. All YRD-lineage LP detected during the fifth wave most likely originated from newly imported viruses into Guangdong. Genotype comparison of HP A/H7N9 suggests limited outward spread of HP A/H7N9 to other provinces. The distribution of HP A/H7N9 cleavage site variants on live poultry markets differed from that found in humans, suggesting a V1-type cleavage site may facilitate human infections.
- Subjects :
- Delta
medicine.medical_specialty
origins
Guangdong
Highly pathogenic
genomic epidemiology
Biology
Microbiology
03 medical and health sciences
highly pathogenic influenza A/H7N9
Virology
Genotype
Epidemiology
medicine
AcademicSubjects/MED00860
030304 developmental biology
0303 health sciences
030306 microbiology
AcademicSubjects/SCI01130
AcademicSubjects/SCI02285
food and beverages
virus diseases
Influenza a
Low pathogenic
Yangtze river
Third wave
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 20571577
- Volume :
- 6
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Virus Evolution
- Accession number :
- edsair.doi.dedup.....fd961aaa10a7b4a4f03d787995a3087e