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Use of JYNNEOS (Smallpox and Monkeypox Vaccine, Live, Nonreplicating) for Preexposure Vaccination of Persons at Risk for Occupational Exposure to Orthopoxviruses: Recommendations of the Advisory Committee on Immunization Practices — United States, 2022

Authors :
Agam K. Rao
Brett W. Petersen
Florence Whitehill
Jafar H. Razeq
Stuart N. Isaacs
Michael J. Merchlinsky
Doug Campos-Outcalt
Rebecca L. Morgan
Inger Damon
Pablo J. Sánchez
Beth P. Bell
Source :
MMWR. Morbidity and Mortality Weekly Report. 71:734-742
Publication Year :
2022
Publisher :
Centers for Disease Control MMWR Office, 2022.

Abstract

Certain laboratorians and health care personnel can be exposed to orthopoxviruses through occupational activities. Because orthopoxvirus infections resulting from occupational exposures can be serious, the Advisory Committee on Immunization Practices (ACIP) has continued to recommend preexposure vaccination for these persons since 1980 (1), when smallpox was eradicated (2). In 2015, ACIP made recommendations for the use of ACAM2000, the only orthopoxvirus vaccine available in the United States at that time (3). During 2020-2021, ACIP considered evidence for use of JYNNEOS, a replication-deficient Vaccinia virus vaccine, as an alternative to ACAM2000. In November 2021, ACIP unanimously voted in favor of JYNNEOS as an alternative to ACAM2000 for primary vaccination and booster doses. With these recommendations for use of JYNNEOS, two vaccines (ACAM2000 and JYNNEOS) are now available and recommended for preexposure prophylaxis against orthopoxvirus infection among persons at risk for such exposures.

Details

ISSN :
1545861X and 01492195
Volume :
71
Database :
OpenAIRE
Journal :
MMWR. Morbidity and Mortality Weekly Report
Accession number :
edsair.doi.dedup.....fd8db04cddfff510dc8683f0d2127940
Full Text :
https://doi.org/10.15585/mmwr.mm7122e1