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Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa
- Publication Year :
- 2001
- Publisher :
- NATURE PUBLISHING GROUP, 2001.
-
Abstract
- The Fulani are less clinically susceptible and more immunologically responsive to malaria than neighbouring ethnic groups. Here we report that anti-malarial antibody levels show a wide distribution amongst the Fulani themselves, raising the possibility that quantitative analysis within the Fulani may be an efficient way of screening for important genetic factors. The Th2 cytokine interleukin-4 is an obvious candidate: in Fulani, the IL4-524 T allele is at high frequency and is associated with elevated antibody levels against malaria antigens. These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting.
- Subjects :
- Male
Genotype
Plasmodium falciparum
Immunology
Antigens, Protozoan
Antibody level
Biology
Polymerase Chain Reaction
ethnic groups
Antibodies
West africa
polymorphism
ethnic group
Gene Frequency
Antigen
Immunity
Polymorphism (computer science)
Ethnicity
Genetics
medicine
Animals
Humans
Genetic Predisposition to Disease
Allele
Promoter Regions, Genetic
Genetics (clinical)
Interleukin 4
Polymorphism, Genetic
malarial immunity
malaria immunity
medicine.disease
Malaria
Africa, Western
Immunoglobulin G
Female
Disease Susceptibility
interleukin-4
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fd886359446ee0ad80a4ca5b0fbce40a