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mGluR5 receptor availability is associated with lower levels of negative symptoms and better cognition in male patients with chronic schizophrenia
- Source :
- Human Brain Mapping, Human brain mapping 41(10), 2762-2781 (2020). doi:10.1002/hbm.24976
- Publication Year :
- 2019
-
Abstract
- Consistent findings postulate disturbed glutamatergic function (more specifically a hypofunction of the ionotropic NMDA receptors) as an important pathophysiologic mechanism in schizophrenia. However, the role of the metabotropic glutamatergic receptors type 5 (mGluR5) in this disease remains unclear. In this study, we investigated their significance (using [11C]ABP688) for psychopathology and cognition in male patients with chronic schizophrenia and healthy controls. In the patient group, lower mGluR5 binding potential (BPND) values in the left temporal cortex and caudate were associated with higher general symptom levels (negative and depressive symptoms), lower levels of global functioning and worse cognitive performance. At the same time, in both groups, mGluR5 BPND were significantly lower in smokers (F [27,1] = 15.500; p = .001), but without significant differences between the groups. Our findings provide support for the concept that the impaired function of mGluR5 underlies the symptoms of schizophrenia. They further supply a new perspective on the complex relationship between tobacco addiction and schizophrenia by identifying glutamatergic neurotransmission—in particularly mGluR5—as a possible connection to a shared vulnerability.
- Subjects :
- Adult
Male
cognition
positron emission tomography
Pyridines
Receptor, Metabotropic Glutamate 5
610 Medicine & health
Neuropsychological Tests
mental disorders
Oximes
2741 Radiology, Nuclear Medicine and Imaging
Humans
Cognitive Dysfunction
ddc:610
chronic schizophrenia
3614 Radiological and Ultrasound Technology
Research Articles
negative symptoms
mGluR5 receptor
Smoking
Middle Aged
2702 Anatomy
Temporal Lobe
2728 Neurology (clinical)
10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics
2808 Neurology
Positron-Emission Tomography
Chronic Disease
Schizophrenia
Caudate Nucleus
Research Article
Subjects
Details
- ISSN :
- 10970193
- Volume :
- 41
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Human brain mapping
- Accession number :
- edsair.doi.dedup.....fd86f9f10f90a1ebbc3fc25b1e26a27c