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Impact of HER2 assessment by CISH in urothelial carcinoma: A retrospective single-center experience
- Source :
- Pathology, research and practice. 220
- Publication Year :
- 2021
-
Abstract
- Background In recent years, HER2 amplification has been evaluated as a potential prognostic biomarker and therapeutic target in urothelial carcinoma (UC). In this retrospective study, we aimed at exploring the prognostic role of HER2 amplification in UC, measured by chromogenic in situ hybridization (CISH). Methods We retrospectively evaluated the presence of HER2 amplification by using CISH in 31 UC patients followed at a single institution between 2018 and 2020. The primary objective was to assess the frequency of HER2 amplification and to compare clinical outcomes of HER2-amplified patients with non-amplified UCs. Results HER2 amplification was identified in 4 out of 31 patients (12.9 %). After a median follow-up of 28.1 months (95 % Confidence Intervals [CI] 11.2–45.1), median overall survival (OS) in the whole population was 10.9 months (95 % CI 3.5–22.1). Despite not reaching statistical significance, median OS was shorter in HER2-amplified patients (6.8 months, 95 % CI 3.9–9.7) compared to HER2-negative UCs (15.4 months, 95 % CI 7.5–23.3) (p = 0.45). Conclusions Although limited by the small sample size, the results of our study suggest that HER2 amplifications by CISH could represent a prognostic factor for shorter survival in UC patients.
- Subjects :
- 0301 basic medicine
Oncology
Male
medicine.medical_specialty
Urologic Neoplasms
Receptor, ErbB-2
Population
Chromogenic in situ hybridization
Single Center
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
HER2
Statistical significance
Internal medicine
Biomarkers, Tumor
Medicine
Humans
ERBB2
skin and connective tissue diseases
education
CISH
In Situ Hybridization
Aged
Retrospective Studies
Aged, 80 and over
education.field_of_study
Bladder cancer
business.industry
Carcinoma
Gene Amplification
Retrospective cohort study
Cell Biology
Middle Aged
medicine.disease
Prognosis
HER family
Confidence interval
030104 developmental biology
Italy
030220 oncology & carcinogenesis
Urothelial carcinoma
Female
Urothelium
business
Subjects
Details
- ISSN :
- 16180631
- Volume :
- 220
- Database :
- OpenAIRE
- Journal :
- Pathology, research and practice
- Accession number :
- edsair.doi.dedup.....fd830366cbffe1bb780a3ff86999bd7c