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The LINA cohort:Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy
- Source :
- Junge, K M, Hörnig, F, Herberth, G, Röder, S, Kohajda, T, Rolle-Kampczyk, U, von Bergen, M, Borte, M, Simon, J C, Heroux, D, Denburg, J A & Lehmann, I 2014, ' The LINA cohort : Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy ', Clinical Immunology, vol. 152, no. 1-2, pp. 68-76 . https://doi.org/10.1016/j.clim.2014.02.013
- Publication Year :
- 2014
-
Abstract
- Rationale Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. Results Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. Conclusions The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.
- Subjects :
- Male
Immunology
Population
Two year old children
Basophil
LINA
Peripheral blood mononuclear cell
Cohort Studies
Pregnancy
Surveys and Questionnaires
Humans
Immunology and Allergy
Medicine
Respiratory system
education
Bronchitis
Respiratory Tract Infections
Th1-Th2 Balance
Volatile Organic Compounds
education.field_of_study
Eosinophil/basophil progenitors
Fetal Stem Cells
Wheezing
business.industry
Infant, Newborn
Infant
Cell Differentiation
Cord blood
Environmental Exposure
Environmental exposure
Eosinophil
Fetal Blood
medicine.disease
Basophils
Eosinophils
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Female
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Junge, K M, Hörnig, F, Herberth, G, Röder, S, Kohajda, T, Rolle-Kampczyk, U, von Bergen, M, Borte, M, Simon, J C, Heroux, D, Denburg, J A & Lehmann, I 2014, ' The LINA cohort : Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy ', Clinical Immunology, vol. 152, no. 1-2, pp. 68-76 . https://doi.org/10.1016/j.clim.2014.02.013
- Accession number :
- edsair.doi.dedup.....fd4b7235fb5983d3510367e365ac51b4
- Full Text :
- https://doi.org/10.1016/j.clim.2014.02.013