Back to Search Start Over

The LINA cohort:Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy

Authors :
Kristin M. Junge
Ulrike Rolle-Kampczyk
Judah A. Denburg
Delia Heroux
Tibor Kohajda
Michael Borte
Jan C. Simon
Friederike Hörnig
Gunda Herberth
Martin von Bergen
Irina Lehmann
Stefan Röder
Source :
Junge, K M, Hörnig, F, Herberth, G, Röder, S, Kohajda, T, Rolle-Kampczyk, U, von Bergen, M, Borte, M, Simon, J C, Heroux, D, Denburg, J A & Lehmann, I 2014, ' The LINA cohort : Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy ', Clinical Immunology, vol. 152, no. 1-2, pp. 68-76 . https://doi.org/10.1016/j.clim.2014.02.013
Publication Year :
2014

Abstract

Rationale Cord blood eosinophil/basophil progenitor cells (Eo/B) of high risk infants have been shown to predict respiratory illnesses in infancy. Here we investigated this association in a population-based cohort. Furthermore, we analysed whether newborns Th1/Th2 balance and prenatal environmental exposure impact Eo/B recruitment. Methods In a sub-cohort of the LINA study cord blood mononuclear cells were used for methylcellulose assays to assess Eo/B differentiation. Questionnaires were recorded during pregnancy and annually thereafter. Volatile organic compounds were measured during pregnancy and cord blood cytokines after ex vivo stimulation. Results Cord blood IL-4 and IL-13 positively correlated with Eo/B. Tobacco smoke related benzene was also positively associated with Eo/B. Enhanced Eo/B numbers increased the risk for wheezing within the first 24 months. Conclusions The association between cord blood Eo/B and respiratory illnesses is not restricted to high-risk children. Prenatal environmental exposure and a Th2 milieu at birth contribute to Eo/B recruitment.

Details

Language :
English
Database :
OpenAIRE
Journal :
Junge, K M, Hörnig, F, Herberth, G, Röder, S, Kohajda, T, Rolle-Kampczyk, U, von Bergen, M, Borte, M, Simon, J C, Heroux, D, Denburg, J A & Lehmann, I 2014, ' The LINA cohort : Cord blood eosinophil/basophil progenitors predict respiratory outcomes in early infancy ', Clinical Immunology, vol. 152, no. 1-2, pp. 68-76 . https://doi.org/10.1016/j.clim.2014.02.013
Accession number :
edsair.doi.dedup.....fd4b7235fb5983d3510367e365ac51b4
Full Text :
https://doi.org/10.1016/j.clim.2014.02.013