Supplementary Figures S1 through S28 from Early Effector T Lymphocytes Coexpress Multiple Inhibitory Receptors in Primary Non–Small Cell Lung Cancer

This file contains 28 Supplementary Figures dealing with: frequency of T cell subsets in tumor and non neoplastic lung tissue (S1), activation and naive to memory profile of T cells at tumor site (S2), functional competence of T cells at tumor site (S3), frequency of PD-1+ T cells in tumor according to clinical stage and patients' survival according to PD-1+ T cell frequency in tumor (S4), Ki-67 vs eomes profile of PD-1+ T cells (S5), expression of Eomes in distinct T cell subsets at tumor site (S6), PD-1 modulation and IFN-g production in PD-1(lo) and PD-1(Hi) T cell subsets (S7), functional competence of T cell subsets according to IRs profile (S8), immunohistochemistry for CD8+FOXP3+ T cells at tumor site (S9-S12), immune profile by immunohistochemistry of lesions containing high frequency of CD8+FOXP3+ T cells (S13-S23), frequency of CD8+FOXP3+ cells at tumor site according to clinical parameters (S24), relationship of CD8+FOXP3+ cells with clinical stage and patients' survival (S25), maturation profile of CD8+FOXP3+ cells (S26), IRs expression and competence for differentiation of CD8+FOXP3+ cells (S27), co-expression of activation/proliferation markers in different T cell subsets at tumor site (S28)