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ASSOCIATION BETWEEN CHOROIDAL CHARACTERISTICS AND SYSTEMIC SEVERITY IN AMYLOIDOSIS
- Source :
- Retina. 41:1037-1046
- Publication Year :
- 2021
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2021.
-
Abstract
- Purpose This study aimed to describe the choroidal features of ocular amyloidosis using multimodal imaging, to correlate these findings with systemic involvement, and to propose a choroidal grading system. Methods Eleven patients with systemic amyloidosis were reviewed retrospectively. Each case was assigned a grade according to the severity of choroidal findings as determined by both enhanced depth imaging optical coherence tomography and indocyanine green angiography. The severity of systemic amyloidosis was then correlated with the choroidal involvement. Results On indocyanine green angiography, all patients exhibited hyperfluorescent spots in the late stage and were classified according to preexisting criteria. On enhanced depth imaging optical coherence tomography, hyperreflective foci were seen in the choriocapillaris and Sattler's layer in Grade 1, partial loss of Sattler's layer was additionally seen in Grade 2, and a dense hyperreflective Haller's layer was seen in Grade 3. Choroidal grading scores were significantly correlated with the systemic severity score (P = 0.0014, Pearson's correlation coefficient; ρ = 0.83). Conclusion With ocular amyloidosis, evaluation of choroidal characteristics using multimodal imaging may serve as a biomarker for systemic involvement.
- Subjects :
- Adult
Male
medicine.medical_specialty
Eye Diseases
Fundus Oculi
Indocyanine green angiography
Multimodal Imaging
03 medical and health sciences
Imaging, Three-Dimensional
0302 clinical medicine
Optical coherence tomography
Ophthalmology
Partial loss
medicine
Humans
Fluorescein Angiography
Aged
Retrospective Studies
Multimodal imaging
medicine.diagnostic_test
Choroid
business.industry
Amyloidosis
Patient Acuity
Late stage
General Medicine
Middle Aged
medicine.disease
eye diseases
Hyperreflective foci
030221 ophthalmology & optometry
Female
sense organs
Enhanced depth imaging
business
Tomography, Optical Coherence
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- ISSN :
- 0275004X
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Retina
- Accession number :
- edsair.doi.dedup.....fd3da2aab9843383a14f65751b2b90bf