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Downregulation of cerebrospinal fluid production in patients with chronic hydrocephalus
- Source :
- Journal of Neurosurgery. 97:1271-1275
- Publication Year :
- 2002
- Publisher :
- Journal of Neurosurgery Publishing Group (JNSPG), 2002.
-
Abstract
- Object. The goal of this study was to determine the effect of hydrocephalus on cerebrospinal fluid (CSF) production rates in patients with acute and chronic hydrocephalus. Methods. The authors studied CSF production both in patients presenting with acute and chronic hydrocephalus, and patients with Parkinson disease (PD) of a similar mean age, whose CSF production was known to be normal. A modification of the Masserman method was used to measure CSF production through a ventricular catheter. The CSF production rates (means ± standard deviations) in the three groups were then compared. The patients with PD had a mean CSF production rate of 0.42 ± 0.13 ml/minute; this value lies within the normal range measured using this technique. Patients with acute hydrocephalus had a similar CSF production rate of 0.4 ± 0.13 ml/minute, whereas patients with chronic hydrocephalus had a significantly decreased mean CSF production rate of 0.25 ± 0.08 ml/minute. Conclusions. The authors postulate that chronic increased intracranial pressure causes downregulation of CSF production.
- Subjects :
- Adult
medicine.medical_specialty
Adolescent
Intracranial Pressure
Urology
Down-Regulation
Central nervous system disease
Cerebrospinal fluid
Downregulation and upregulation
medicine
Humans
In patient
Child
Aged
Cerebrospinal Fluid
Intracranial pressure
business.industry
Middle Aged
medicine.disease
Pathophysiology
Surgery
Hydrocephalus
Cerebrovascular Circulation
Acute Disease
Choroid Plexus
Chronic Disease
Choroid plexus
business
Subjects
Details
- ISSN :
- 00223085
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Journal of Neurosurgery
- Accession number :
- edsair.doi.dedup.....fd3195abc03da1c1095acae7806fae22