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Tranexamic Acid Does Not Influence Cardioprotection by Ischemic Preconditioning and Remote Ischemic Preconditioning
- Source :
- Anesthesia and analgesia, 126(2), 439-442. Lippincott Williams and Wilkins
- Publication Year :
- 2018
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2018.
-
Abstract
- Prior studies have suggested that the antifibrinolytic drug aprotinin increases the infarct size after ischemia and reperfusion (I/R) and attenuates the effect of ischemic preconditioning (IPC). Aprotinin was replaced by tranexamic acid (TXA) in clinical practice. Here, we investigated whether TXA influences I/R injury and/or cardioprotection initiated by IPC and/or remote ischemic preconditioning (RIPC). Anesthetized male Wistar rats were randomized to 6 groups. Control animals were not further treated. Administration of TXA was combined with and without IPC and RIPC. Estimated treatment effect was 20%. Compared to control group (56% ± 11%), IPC reduced infarct size by 46% (30% ± 6%; mean difference, 26%; 95% confidence interval, 19-33; P < .0001), and RIPC reduced infarct size by 29% (40% ± 8%; mean difference, 16%; 95% confidence interval, 9-24; P < .011). Additional application of TXA had no effect on I/R injury and cardioprotection by IPC or RIPC. TXA does not abolish infarct size reduction by IPC or RIPC.
- Subjects :
- Male
medicine.medical_specialty
Antifibrinolytic
medicine.drug_class
Myocardial Ischemia
Ischemia
030204 cardiovascular system & hematology
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Antifibrinolytic agent
parasitic diseases
medicine
Animals
Aprotinin
cardiovascular diseases
Rats, Wistar
Cardioprotection
business.industry
030208 emergency & critical care medicine
medicine.disease
Antifibrinolytic Agents
Confidence interval
Rats
Anesthesiology and Pain Medicine
Tranexamic Acid
Ischemic Preconditioning, Myocardial
Cardiology
Ischemic preconditioning
business
Tranexamic acid
medicine.drug
Subjects
Details
- ISSN :
- 00032999
- Volume :
- 126
- Database :
- OpenAIRE
- Journal :
- Anesthesia & Analgesia
- Accession number :
- edsair.doi.dedup.....fd20093aaeea27f39dbb99825f86fa34