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Taurine supplementation has anti-atherogenic and anti-inflammatory effects before and after incremental exercise in heart failure
- Source :
- Therapeutic Advances in Cardiovascular Disease. 11:185-194
- Publication Year :
- 2017
- Publisher :
- SAGE Publications, 2017.
-
Abstract
- Background: The purpose of this study was to examine the anti-atherogenic and anti-inflammatory effect of supplemental taurine prior to and following incremental exercise in patients with heart failure (HF). Methods: Patients with HF and left ventricle ejection fraction less than 50%, and placed in functional class II or III according to the New York Heart Association classification, were randomly assigned to two groups: (1) taurine supplementation; or (2) placebo. The taurine group received oral taurine (500 mg) 3 times a day for 2 weeks, and performed exercise before and after the supplementation period. The placebo group followed the same protocol, but with a starch supplement (500 mg) rather than taurine. The incremental multilevel treadmill test was done using a modified Bruce protocol. Results: Our results indicate that inflammatory indices [C-reactive protein (CRP), platelets] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05) whereas these indices increased in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation in the placebo group ( p < 0.05). Our results also show that atherogenic indices [Castelli’s Risk Index-I (CRI-I), Castelli’s Risk Index-II (CRI-II) and Atherogenic Coefficient (AC)] decreased in the taurine group in pre-exercise, post-supplementation and post-exercise, post-supplementation as compared with pre-exercise, pre-supplementation ( p < 0.05). No such changes were noted in the placebo group ( p > 0.05). Conclusions: our results suggest that 2 weeks of oral taurine supplementation increases the taurine levels and has anti-atherogenic and anti-inflammatory effects prior to and following incremental exercise in HF patients.
- Subjects :
- Blood Platelets
0301 basic medicine
medicine.medical_specialty
Taurine
Time Factors
Anti-Inflammatory Agents
Iran
030204 cardiovascular system & hematology
Placebo
Ventricular Function, Left
Incremental exercise
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
Pharmacology (medical)
Platelet
Treadmill
Exercise
Original Research
Aged
Hypolipidemic Agents
Heart Failure
Ejection fraction
business.industry
Stroke Volume
Middle Aged
medicine.disease
Lipids
C-Reactive Protein
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Endocrinology
chemistry
Ventricle
Heart failure
Dietary Supplements
Exercise Test
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Biomarkers
Subjects
Details
- ISSN :
- 17539455 and 17539447
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Therapeutic Advances in Cardiovascular Disease
- Accession number :
- edsair.doi.dedup.....fd1877186436225b547fd2608cae0e92