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Epstein-Barr virus infection in gliomas
- Source :
- Current research in translational medicine. 67(4)
- Publication Year :
- 2019
-
Abstract
- Purpose of the study Epstein-Barr virus (EBV) has been involved in the development of some tumors, including Burkitt's lymphoma and Hodgkin's lymphoma. However, its potential role in glioma tumorigenesis remains debated. In this study, we investigated the EBV infection in gliomas from Tunisian patients. Patients and methods We conducted a retrospective study of 112 gliomas on archival material. The EBV DNA sequence was analyzed by polymerase chain reaction (PCR). Latent membrane protein 1 (LMP1) was detected by immunohistochemistry. In situ hybridization was used to detect EBV encoded small RNA (EBER). Clinicopathological features were recorded. Survival analysis was carried out using the Kaplan-Meier method and the Log-Rank test to compare EBV-positive and EBV-negative patients. Results Overall, there were twenty-four EBV-positive gliomas (21.4%). EBV DNA was identified in 24 cases. LMP1 and EBER were detected in four EBV DNA-positive cases. All EBV-positive cases were glioblastomas multiforme (GBM). Median overall survival and recurrence-free survival of EBV-negative patients were better than those of EBV-positive patients (Log Rank p = 0.006). Conclusion Altogether, these findings support the occurrence of EBV infection in Tunisian GBM. Furthermore, when compared to EBV-negative tumors, EBV infection seems to be associated with the worst patient prognosis. Advanced molecular studies are recommended to confirm these results and to shed further light on the potential role of EBV in these devastating tumors.
- Subjects :
- 0301 basic medicine
Adult
Male
Epstein-Barr Virus Infections
Herpesvirus 4, Human
Tunisia
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Virus
law.invention
03 medical and health sciences
Young Adult
0302 clinical medicine
law
hemic and lymphatic diseases
Glioma
medicine
Humans
Epstein–Barr virus infection
Polymerase chain reaction
Survival analysis
Aged
Retrospective Studies
business.industry
Brain Neoplasms
General Medicine
Middle Aged
medicine.disease
Cell Transformation, Viral
Prognosis
Lymphoma
030104 developmental biology
030220 oncology & carcinogenesis
Cancer research
Immunohistochemistry
Female
Neoplasm Grading
Carcinogenesis
business
Subjects
Details
- ISSN :
- 24523186
- Volume :
- 67
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Current research in translational medicine
- Accession number :
- edsair.doi.dedup.....fd09f86b0576b435c110a16527c9edc3