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Molecular epidemiology of tuberculosis in a sentinel surveillance population
- Source :
- Emerging Infectious Diseases, Emerging Infectious Diseases, Vol 8, Iss 11, Pp 1197-1209 (2002)
- Publication Year :
- 2002
-
Abstract
- We conducted a population-based study to assess demographic and risk-factor correlates for the most frequently occurring Mycobacterium tuberculosis genotypes from tuberculosis (TB) patients. The study included all incident, culture-positive TB patients from seven sentinel surveillance sites in the United States from 1996 to 2000. M. tuberculosis isolates were genotyped by IS6110-based restriction fragment length polymorphism and spoligotyping. Genotyping was available for 90% of 11,923 TB patients. Overall, 48% of cases had isolates that matched those from another patient, including 64% of U.S.-born and 35% of foreign-born patients. By logistic regression analysis, risk factors for clustering of genotypes were being male, U.S.-born, black, homeless, and infected with HIV; having pulmonary disease with cavitations on chest radiograph and a sputum smear with acid-fast bacilli; and excessive drug or alcohol use. Molecular characterization of TB isolates permitted risk correlates for clusters and specific genotypes to be described and provided information regarding cluster dynamics over time.
- Subjects :
- Male
Time Factors
Epidemiology
Antitubercular Agents
lcsh:Medicine
Risk Factors
Drug Resistance, Multiple, Bacterial
Genotype
Cluster Analysis
Longitudinal Studies
Child
education.field_of_study
Molecular Epidemiology
biology
Dispatch
Middle Aged
Infectious Diseases
insertion sequence elements
Child, Preschool
Female
Restriction fragment length polymorphism
medicine.symptom
Polymorphism, Restriction Fragment Length
Microbiology (medical)
Adult
DNA, Bacterial
medicine.medical_specialty
Tuberculosis
Adolescent
Population
Sentinel surveillance
lcsh:Infectious and parasitic diseases
Mycobacterium tuberculosis
Internal medicine
medicine
Humans
lcsh:RC109-216
education
Genotyping
Aged
Molecular epidemiology
business.industry
lcsh:R
Racial Groups
Infant
restriction fragment-length polymorphism
biology.organism_classification
medicine.disease
United States
Immunology
Sputum
business
Subjects
Details
- ISSN :
- 10806040
- Volume :
- 8
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Emerging infectious diseases
- Accession number :
- edsair.doi.dedup.....fd023f87a22989c31fa3ad968718c524