Back to Search
Start Over
D1 Receptor Modulation of Action Potential Firing in a Subpopulation of Layer 5 Pyramidal Neurons in the Prefrontal Cortex
- Source :
- Journal of Neuroscience. 32:10516-10521
- Publication Year :
- 2012
- Publisher :
- Society for Neuroscience, 2012.
-
Abstract
- Dopamine modulation in the prefrontal cortex is important for cognitive processing and disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to enable working memory by enhancing the firing properties of pyramidal neurons. However, these receptors are only sparsely expressed in the prefrontal cortex, and how they impact individual neurons remains unknown. Here we study D1 receptor modulation of layer 5 pyramidal neurons in acute slices of the mouse prefrontal cortex. Using whole-cell recordings and two-photon microscopy, we show that neurons expressing D1 receptors have unique morphological and physiological properties. We then demonstrate that activation of these receptors selectively enhances the firing of these neurons by signaling via the protein kinase A pathway. This finding of robust D1 receptor modulation in only a subpopulation of neurons has important implications for cognitive function and disease.
- Subjects :
- Male
Patch-Clamp Techniques
Biophysics
Action Potentials
Prefrontal Cortex
Mice, Transgenic
In Vitro Techniques
Biology
Piperazines
Article
GABA Antagonists
Mice
Dopamine receptor D1
Dopamine
Quinoxalines
medicine
Animals
Patch clamp
Enzyme Inhibitors
Receptor
Prefrontal cortex
Microscopy, Confocal
Working memory
Pyramidal Cells
Receptors, Dopamine D1
General Neuroscience
GABA receptor antagonist
Electric Stimulation
Pyridazines
Animals, Newborn
nervous system
Dopamine Antagonists
Female
Plant Lectins
Signal transduction
Excitatory Amino Acid Antagonists
Neuroscience
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15292401 and 02706474
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Neuroscience
- Accession number :
- edsair.doi.dedup.....fcf8561fef6b2f0e7a22a5d6310f488b