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Effects of B-HT 920 and B-HT 933 on Dopamine and Noradrenaline Autoreceptors in the Rat Brain
- Source :
- Acta Pharmacologica et Toxicologica. 52:51-56
- Publication Year :
- 2009
- Publisher :
- Wiley, 2009.
-
Abstract
- B-HT 920 at low doses inhibited the accumulation of DOPA following treatment with reserpine and a DOPA decarboxylase inhibitor in the dopamine-, but not in the noradrenaline-predominant regions of the rat brain. B-HT 933 selectively inhibited this DOPA accumulation in the noradrenaline-predominant regions. These effects of B-HT 920 and B-HT 933 were completely antagonized by haloperidol and yohimbine, respectively. The rat motor activity was reduced by B-HT 920 and it was restored following apomorphine. B-HT 933 decreased the motor activity by a yohimbine-sensitive mechanism. The results indicate that B-HT 920 can selectively and potently stimulate the dopamine autoreceptors whereas B-HT 933 can selectively stimulate the noradrenaline autoreceptors.
- Subjects :
- Male
medicine.medical_specialty
Dopamine
Motor Activity
Toxicology
Receptors, Dopamine
Internal medicine
medicine
Haloperidol
Animals
Brain Chemistry
Pharmacology
Aromatic L-amino acid decarboxylase
Chemistry
Rats, Inbred Strains
Azepines
Reserpine
Talipexole
Dihydroxyphenylalanine
Rats
Receptors, Adrenergic
Yohimbine
Apomorphine
Endocrinology
Autoreceptor
medicine.drug
Subjects
Details
- ISSN :
- 00016683
- Volume :
- 52
- Database :
- OpenAIRE
- Journal :
- Acta Pharmacologica et Toxicologica
- Accession number :
- edsair.doi.dedup.....fcf2989a5dda8496d69cef20929091f3