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Prevalence of Gene Rearrangements in Mexican Children with Acute Lymphoblastic Leukemia: A Population Study—Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia
- Source :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Mexico has one of the highest incidences of childhood leukemia worldwide and significantly higher mortality rates for this disease compared with other countries. One possible cause is the high prevalence of gene rearrangements associated with the etiology or with a poor prognosis of childhood acute lymphoblastic leukemia (ALL). The aims of this multicenter study were to determine the prevalence of the four most common gene rearrangements [ETV6-RUNX1, TCF3-PBX1, BCR-ABL1, andMLLrearrangements] and to explore their relationship with mortality rates during the first year of treatment in ALL children from Mexico City. Patients were recruited from eight public hospitals during 2010–2012. A total of 282 bone marrow samples were obtained at each child’s diagnosis for screening by conventional and multiplex reverse transcription polymerase chain reaction to determine the gene rearrangements. Gene rearrangements were detected in 50 (17.7%) patients.ETV6-RUNX1was detected in 21 (7.4%) patients,TCF3-PBX1in 20 (7.1%) patients,BCR-ABL1in 5 (1.8%) patients, andMLLrearrangements in 4 (1.4%) patients. The earliest deaths occurred at months 1, 2, and 3 after diagnosis in patients withMLL, ETV6-RUNX1, andBCR-ABL1gene rearrangements, respectively. Gene rearrangements could be related to the aggressiveness of leukemia observed in Mexican children.
- Subjects :
- Pediatrics
medicine.medical_specialty
Article Subject
Childhood leukemia
Adolescent
Oncogene Proteins, Fusion
lcsh:Medicine
HL-60 Cells
General Biochemistry, Genetics and Molecular Biology
Disease-Free Survival
hemic and lymphatic diseases
Prevalence
Medicine
Humans
Child
Childhood Acute Lymphoblastic Leukemia
Survival rate
Mexico
Gene Rearrangement
General Immunology and Microbiology
business.industry
Mortality rate
lcsh:R
General Medicine
Gene rearrangement
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Survival Rate
Leukemia
Child, Preschool
Etiology
Population study
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....fcebe8dd8040904f62f8a5e8601feb33