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Development of refractive errors - what can we learn from inherited retinal dystrophies?
- Source :
- American Journal of Ophthalmology, 182, 81-89. Elsevier Inc., Hendriks, M, Verhoeven, V J M, Buitendijk, G H S, Polling, J R, Meester-Smoor, M A, Hofman, A, Kamermans, M, Ingeborgh van den Born, L, Klaver, C C W & RD5000 Consortium 2017, ' Development of Refractive Errors—What Can We Learn From Inherited Retinal Dystrophies? ', American Journal of Ophthalmology, vol. 182, pp. 81-89 . https://doi.org/10.1016/j.ajo.2017.07.008, American Journal of Ophthalmology, 182, 81-89, American Journal of Ophthalmology, 182, 81-89. Elsevier USA, American Journal of Ophthalmology, 182, pp. 81-89, American Journal of Ophthalmology, 182, 81. Elsevier USA, American Journal of Ophthalmology, American journal of ophthalmology, 182, 81-89. Elsevier USA
- Publication Year :
- 2017
-
Abstract
- PURPOSE: It is unknown which retinal cells are involved in the retina-to-sclera signaling cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by dysfunction of a single retinal cell type and have a high risk of refractive errors, a study investigating the affected cell type, causal gene, and refractive error in IRDs may provide insight herein. DESIGN: Case-control study. METHODS: STUDY POPULATION: Total of 302 patients with IRD. from 2 ophthalmogenetic centers in the Netherlands. REFERENCE POPULATION: Population-based Rotterdam Study-III and Erasmus Rucphen Family Study (N = 5550). Distributions and mean spherical equivalent (SE) were calculated for main affected cell type and causal gene; and risks of myopia and hyperopia were evaluated using logistic regression. RESULTS: Bipolar cell-related dystrophies were associated with the highest risk of SE high myopia 239.7; odds ratio (OR) mild hyperopia 263.2, both P
- Subjects :
- 0301 basic medicine
Male
Refractive error
genetic structures
DNA Mutational Analysis
Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12]
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Myopia
Medicine
Dioptre
education.field_of_study
Eye Diseases, Hereditary
Middle Aged
3. Good health
medicine.anatomical_structure
Hyperopia
Population study
Female
Retinal Dystrophies
Adult
medicine.medical_specialty
Retinal Bipolar Cells
Calcium Channels, L-Type
Population
03 medical and health sciences
Ophthalmology
Journal Article
Humans
Retinal Photoreceptor Cell Inner Segment
education
Eye Proteins
Retinal pigment epithelium
business.industry
Calcium-Binding Proteins
Retinal
Odds ratio
medicine.disease
Retinal Photoreceptor Cell Outer Segment
eye diseases
030104 developmental biology
chemistry
Case-Control Studies
Mutation
Synapses
030221 ophthalmology & optometry
sense organs
business
Subjects
Details
- Language :
- English
- ISSN :
- 00029394
- Volume :
- 182
- Database :
- OpenAIRE
- Journal :
- American Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....fcea991019b6ecc07882ea584a3c484a