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Candida glabrata is an emerging cause of oropharyngeal candidiasis in patients receiving radiation for head and neck cancer
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 97:47-52
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- Oropharyngeal candidiasis (OPC) is relatively common in patients receiving radiation for head and neck cancer occurring in approximately 25% of patients. Candida albicans has been described as the primary infecting organism. Recently, other organisms, particularly Candida glabrata, have emerged as causative agents of OPC among immunocompromised patients. This study describes the characteristics of 6 patients with head and neck cancer treated with radiotherapy at our institution, who were found to have Candida glabrata-associated OPC and their responses to oral fluconazole. All 6 patients were successfully treated with oral fluconazole. However, most did not respond to the usual dose of 100 mg/day necessitating doses ranging from 200 to 800 mg/day to achieve clinical cure. All 3 patients receiving radiation only were successfully treated with up to 200 mg/day; 2 of 3 patients receiving concomitant chemoradiation required doses ranging from 400 to 800 mg/day. As with systemic infection, previous fluconazole use appears to be a risk factor for this infection, but not with all patients.
- Subjects :
- Adult
Male
medicine.medical_specialty
Antifungal Agents
medicine.medical_treatment
Oropharynx
Candida glabrata
Opportunistic Infections
Gastroenterology
Oropharyngeal Candidiasis
Immunocompromised Host
Candidiasis, Oral
Drug Resistance, Fungal
Internal medicine
medicine
Humans
Candida albicans
Fluconazole
General Dentistry
Mycosis
Aged
biology
Head and neck cancer
Pharyngeal Diseases
Middle Aged
medicine.disease
biology.organism_classification
Surgery
Radiation therapy
stomatognathic diseases
Otorhinolaryngology
Chemotherapy, Adjuvant
Concomitant
Carcinoma, Squamous Cell
Mouth Neoplasms
Oral Surgery
medicine.drug
Subjects
Details
- ISSN :
- 10792104
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- Accession number :
- edsair.doi.dedup.....fce297d8b82136f7192d61278369edb5