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Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck
- Source :
- Journal of Experimental & Clinical Cancer Research : CR, Journal of Experimental & Clinical Cancer Research, Vol 28, Iss 1, p 37 (2009)
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Background The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single nucleotide polymorphisms (SNPs) of XRCC1 gene with human head and neck squamous cell carcinoma (HNSCC). Methods The genotype analysis of Arg194Trp and Arg399Gln gene polymorphisms for 92 HNSCC patients and 124 controls of cancer free subjects, in Polish population were performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP) with endonuclease Msp I. Results No altered risk has been found individually for these SNPs, however haplotypes analysis showed high association with head and neck cancer. The highest frequency, according to wild-type of Arg194Arg and Arg399Arg genotypes, was identified for Arg194Trp-Arg399Arg haplotype (OR, 2.96; 95% CI, 1.01–8.80). Conclusion Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene XRCC1 that was associated with HNSCC and may have an impact on identification of a high-risk cancer population.
- Subjects :
- Adult
Male
Oncology
Cancer Research
medicine.medical_specialty
DNA Repair
Genotype
Population
Single-nucleotide polymorphism
Biology
lcsh:RC254-282
XRCC1
Gene Frequency
Internal medicine
medicine
Humans
Genetic Predisposition to Disease
education
XRCC1 Gene
education.field_of_study
Polymorphism, Genetic
Research
Haplotype
Cancer
DNA, Neoplasm
Base excision repair
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
DNA-Binding Proteins
X-ray Repair Cross Complementing Protein 1
Head and Neck Neoplasms
Case-Control Studies
Carcinoma, Squamous Cell
Cancer research
Female
Subjects
Details
- ISSN :
- 17569966
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental & Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....fcdd43a298b35a706c33e4cb7c1b7804
- Full Text :
- https://doi.org/10.1186/1756-9966-28-37