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Genetic polymorphisms in DNA base excision repair gene XRCC1 and the risk of squamous cell carcinoma of the head and neck

Authors :
Karolina Przybyłowska
Ireneusz Majsterek
Szemraj Janusz
Pawel Rusin
Michał Kowalski
Jurek Olszewski
Wioletta Pietruszewska
Wojciech Młynarski
Alina Morawiec-Sztandera
Anna Bielecka-Kowalska
Source :
Journal of Experimental & Clinical Cancer Research : CR, Journal of Experimental & Clinical Cancer Research, Vol 28, Iss 1, p 37 (2009)
Publication Year :
2009
Publisher :
Springer Science and Business Media LLC, 2009.

Abstract

Background The genes of base excision repair (BER) pathway have been extensively studied in the association with various human cancers. We performed a case-control study to test the association between two common single nucleotide polymorphisms (SNPs) of XRCC1 gene with human head and neck squamous cell carcinoma (HNSCC). Methods The genotype analysis of Arg194Trp and Arg399Gln gene polymorphisms for 92 HNSCC patients and 124 controls of cancer free subjects, in Polish population were performed using the PCR-based restriction fragment length polymorphism (PCR-RFLP) with endonuclease Msp I. Results No altered risk has been found individually for these SNPs, however haplotypes analysis showed high association with head and neck cancer. The highest frequency, according to wild-type of Arg194Arg and Arg399Arg genotypes, was identified for Arg194Trp-Arg399Arg haplotype (OR, 2.96; 95% CI, 1.01–8.80). Conclusion Finally, we identified the combined Arg194Trp-Arg399Arg genotype of base excision repair gene XRCC1 that was associated with HNSCC and may have an impact on identification of a high-risk cancer population.

Details

ISSN :
17569966
Volume :
28
Database :
OpenAIRE
Journal :
Journal of Experimental & Clinical Cancer Research
Accession number :
edsair.doi.dedup.....fcdd43a298b35a706c33e4cb7c1b7804
Full Text :
https://doi.org/10.1186/1756-9966-28-37