Back to Search
Start Over
Theory to predict shear stress on cells in turbulent blood flow
- Source :
- PLoS ONE, Vol 9, Iss 8, p e105357 (2014), PLoS ONE
- Publication Year :
- 2014
- Publisher :
- Public Library of Science (PLoS), 2014.
-
Abstract
- Shear stress on blood cells and platelets transported in a turbulent flow dictates the fate and biological activity of these cells. We present a theoretical link between energy dissipation in turbulent flows to the shear stress that cells experience and show that for the case of physiological turbulent blood flow: (a) the Newtonian assumption is valid, (b) turbulent eddies are universal for the most complex of blood flow problems, and (c) shear stress distribution on turbulent blood flows is possibly universal. Further we resolve a long standing inconsistency in hemolysis between laminar and turbulent flow using the theoretical framework. This work demonstrates that energy dissipation as opposed to bulk shear stress in laminar or turbulent blood flow dictates local mechanical environment of blood cells and platelets universally.
- Subjects :
- Platelets
Work (thermodynamics)
Quantitative Biology::Tissues and Organs
0206 medical engineering
Cardiology
lcsh:Medicine
02 engineering and technology
030204 cardiovascular system & hematology
Quantitative Biology::Cell Behavior
Physics::Fluid Dynamics
03 medical and health sciences
Motion
0302 clinical medicine
Animal Cells
Biological Fluid Mechanics
Molecular Cell Biology
Newtonian fluid
Shear stress
Medicine and Health Sciences
Biomechanics
lcsh:Science
Newton's Laws of Motion
Physics
Multidisciplinary
Blood Cells
Turbulence
lcsh:R
Hemodynamics
Biology and Life Sciences
Classical Mechanics
Laminar flow
Blood flow
Mechanics
Cell Biology
Hematology
Dissipation
020601 biomedical engineering
Body Fluids
Blood
Eddy
Physical Sciences
Physics::Space Physics
lcsh:Q
Anatomy
Cellular Types
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 9
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....fcd8096205e780c28ad61909e29b6e9e