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The Incidence of Chronic Kidney Disease Three Years after Non-Severe Acute Kidney Injury in Critically Ill Patients: A Single-Center Cohort Study
- Source :
- Journal of Clinical Medicine, Volume 8, Issue 12
- Publication Year :
- 2019
- Publisher :
- MDPI, 2019.
-
Abstract
- The risk of chronic kidney disease (CKD) following severe acute kidney injury (AKI) in critically ill patients is well documented, but not after less severe AKI. The main objective of this study was to evaluate the long-term incidence of CKD after non-severe AKI in critically ill patients. This prospective single-center observational three-years follow-up study was conducted in the medical intensive care unit in Bordeaux&rsquo<br />s hospital (France). From 2013 to 2015, all patients with severe (kidney disease improving global outcomes (KDIGO) stage 3) and non-severe AKI (KDIGO stages 1, 2) were enrolled. Patients with prior eGFR &lt<br />90 mL/min/1.73 m2 were excluded. Primary outcome was the three-year incidence of CKD stages 3 to 5 in the non-severe AKI group. We enrolled 232 patients. Non-severe AKI was observed in 112 and severe AKI in 120. In the non-severe AKI group, 71 (63%) were male, age was 62 &plusmn<br />16 years. The reason for admission was sepsis for 56/112 (50%). Sixty-two (55%) patients died and nine (8%) were lost to follow-up. At the end of the follow-up the incidence of CKD was 22% (9/41)<br />Confidence Interval (CI) 95% (9.3&ndash<br />33.60)% in the non-severe AKI group, tending to be significantly lower than in the severe AKI group (44% (14/30)<br />CI 95% (28.8&ndash<br />64.5)%<br />p = 0.052). The development of CKD three years after non-severe AKI, despite it being lower than after severe AKI, appears to be a frequent event highlighting the need for prolonged follow-up.
- Subjects :
- medicine.medical_specialty
critically ill patients
030232 urology & nephrology
macromolecular substances
Single Center
urologic and male genital diseases
Article
End stage renal disease
Sepsis
03 medical and health sciences
0302 clinical medicine
renal recovery
Internal medicine
Medicine
030212 general & internal medicine
end stage renal disease
business.industry
urogenital system
Incidence (epidemiology)
Acute kidney injury
General Medicine
medicine.disease
Confidence interval
female genital diseases and pregnancy complications
nervous system
acute kidney injury
business
chronic kidney disease
Kidney disease
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 8
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....fccdb21b8a50e77164d9ed746ce8df1c