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The diagnostic accuracy of the faecal immunohistochemical test in identifying significant bowel disease in a symptomatic population
- Source :
- Colorectal Disease. 24:257-263
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- AIM Provisional research on the faecal immunohistochemical test (FIT) for symptomatic colorectal patients has shown a high negative predictive value but has lacked long-term patient follow-up, raising the possibility of missed diagnoses of colorectal cancer (CRC). The aim of this work is to describe the long-term diagnostic accuracy of the FIT for CRC and significant bowel disease (SBD) in a symptomatic population in NHS Lanarkshire. METHOD From October 2016 to February 2019, all primary care referrals of symptomatic colorectal patients in NHS Lanarkshire were asked to provide a FIT. The baseline demographics, investigations and diagnoses for each patient were prospectively completed until February 2021. A FIT result of ≥10 μg haemoglobin (Hb)/g faeces was considered to be positive. RESULTS A total of 5250 patients were identified (median age 62 years; 46% male; median follow-up 31 months) with 65.1% (3418) being FIT negative. The SBD rate was 6.2% and the CRC rate was 2.9% (151). The SBD rate was significantly higher in the FIT-positive group (13.8% vs. 2.2%; p
- Subjects :
- Male
medicine.medical_specialty
Referral
Colorectal cancer
Population
Colonoscopy
Disease
Sensitivity and Specificity
Feces
Hemoglobins
Internal medicine
Epidemiology
medicine
Humans
education
Early Detection of Cancer
education.field_of_study
medicine.diagnostic_test
business.industry
Gastroenterology
Cancer
Sigmoidoscopy
Middle Aged
medicine.disease
Intestinal Diseases
Occult Blood
Female
Colorectal Neoplasms
business
Subjects
Details
- ISSN :
- 14631318 and 14628910
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Colorectal Disease
- Accession number :
- edsair.doi.dedup.....fcc7e782dbe787a1bde29633a46f9597