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Perfusion of the Placenta assessed using Arterial Spin Labeling and Ferumoxytol Dynamic Contrast Enhanced Magnetic Resonance Imaging in the Rhesus Macaque
- Publication Year :
- 2018
-
Abstract
- PURPOSE: To investigate the correspondence between arterial spin labeling (ASL) flow-sensitive alternating inversion recovery (FAIR) and ferumoxytol dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) for the assessment of placental intervillous perfusion. METHODS: Ten pregnant macaques in late 2(nd) trimester were imaged at 3T using a 2D ASL FAIR, with and without outer volume saturation (OVS) pulses used to control the bolus width, and a 3D ferumoxytol DCE MRI acquisition. ASL tagged/control pairs were averaged, subtracted, and normalized to create perfusion ratio maps. Contrast arrival time and uptake slope were estimated by fitting DCE data to a sigmoid function. Macaques (N=4) received interleukin-1β to induce inflammation and disrupt perfusion. RESULTS: FAIR tag modification with OVS reduced median ASL ratio percentage compared to conventional FAIR (0.64±1.42% vs. 0.71±2.00%;p0.05). CONCLUSION: ASL FAIR and ferumoxytol DCE MRI are feasible methods to detect early blood delivery to the macaque placenta. OVS reduced high macrovascular ASL signal. Interleukin-1β exposure did not alter placental intervillous perfusion. An endogenous-labeling perfusion technique is limited due to extended transit times for flow within the placenta beyond the immediate vicinity of the maternal spiral arteries.
- Subjects :
- Amniotic fluid
Placenta
Interleukin-1beta
Contrast Media
Macaque
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Pregnancy
biology.animal
medicine
otorhinolaryngologic diseases
Image Processing, Computer-Assisted
Animals
Radiology, Nuclear Medicine and imaging
Inflammation
medicine.diagnostic_test
biology
business.industry
Magnetic resonance imaging
Arteries
biology.organism_classification
Macaca mulatta
Magnetic Resonance Imaging
Ferrosoferric Oxide
Ferumoxytol
Perfusion
Rhesus macaque
medicine.anatomical_structure
Pregnancy, Animal
Female
Spin Labels
Bolus (digestion)
business
Nuclear medicine
030217 neurology & neurosurgery
Magnetic Resonance Angiography
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....fcb60d753983eec6dacaaa21eabd7a1b