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Clinical impact of estradiol/testosterone ratio in patients with acute ischemic stroke
- Source :
- BMC Neurology, BMC Neurology, Vol 21, Iss 1, Pp 1-11 (2021)
- Publication Year :
- 2020
-
Abstract
- Background Sex hormones may be associated with a higher incidence of ischemic stroke or stroke-related events. In observational studies, lower testosterone concentrations are associated with infirmity, vascular disease, and adverse cardiovascular risk factors. Currently, female sexual hormones are considered neuroprotective agents. The purpose of this study was to assess the role of sex hormones and the ratio of estradiol/testosterone (E/T) in patients with acute ischemic stroke (AIS). Methods Between January 2011 and December 2016, 146 male patients with AIS and 152 age- and sex-matched control subjects were included in this study. Sex hormones, including estradiol, progesterone, and testosterone, were evaluated in the AIS patient and control groups. We analyzed the clinical and physiological levels of sex hormones and hormone ratios in these patients. Results The E/T ratio was significantly elevated among patients in the stroke group compared to those in the control group (P = 0.001). Categorization of data into tertiles revealed that patients with the highest E/T ratio were more likely to have AIS [odds ratio (OR) 3.084; 95% Confidence interval (CI): 1.616-5.886; P < 0.001) compared with those in the first tertile. The E/T ratio was also an independent unfavorable outcome predictor with an adjusted OR of 1.167 (95% CI: 1.053-1.294; P = 0.003). Conclusions These findings support the hypothesis that increased estradiol and reduced testosterone levels are associated with AIS in men.
- Subjects :
- Male
medicine.medical_specialty
Neurology
Acute ischemic stroke
Physiology
lcsh:RC346-429
03 medical and health sciences
estradiol/testosterone ratio
0302 clinical medicine
Odds Ratio
Medicine
Humans
Testosterone
Sex hormones
Prospective Studies
Stroke
lcsh:Neurology. Diseases of the nervous system
030304 developmental biology
Aged
Ischemic Stroke
0303 health sciences
Estradiol
business.industry
Vascular disease
Incidence (epidemiology)
Incidence
Men
General Medicine
Odds ratio
Middle Aged
Functional outcome
medicine.disease
Confidence interval
Neurology (clinical)
business
030217 neurology & neurosurgery
Hormone
Research Article
Subjects
Details
- ISSN :
- 14712377
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC neurology
- Accession number :
- edsair.doi.dedup.....fcb53023760d0f417c38aa30ddd499b7