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The SREBF-1 locus is associated with type 2 diabetes and plasma adiponectin levels in a middle-aged Austrian population
- Source :
- International Journal of Obesity. 31:1099-1103
- Publication Year :
- 2006
- Publisher :
- Springer Science and Business Media LLC, 2006.
-
Abstract
- The sterol regulatory element-binding protein-1c (SREBP-1c) is a transcription factor involved in the regulation of lipid and glucose metabolism and has been implicated in the pathophysiology of type 2 diabetes mellitus (T2DM). We aimed to confirm associations of the SREBF-1 gene with T2DM in an Austrian population and to study possible associations with diabetes-related quantitative traits. We genotyped a diabetic cohort (n=446) along with a control group (n=1524) for a common C/G variation that is located in exon 18c (rs2297508) and has been associated with obesity and T2DM in French populations. Body mass index (BMI), indices of insulin sensitivity and β-cell function, plasma adiponectin, T2DM and single-nucleotide polymorphism rs2297508. Genotype distributions associated with rs2297508 differed by T2DM status (P=0.0045), but not by BMI. The variant G allele was associated with a modest, but significant, increase in the prevalence of T2DM after adjustment for age, sex and BMI (G/G: odds ratios (OR) (95% confidence intervals)=1.45 (0.99–2.11) and G/C: OR=1.37 (1.04–1.81)). In a cross-sectional population of non-diabetic subjects, associations of rs2297508 genotypes with plasma adiponectin levels adjusted for age, sex and BMI (P=0.0017) were observed in that the risk G/G genotype displayed the lowest adiponectin levels. We observed associations of rs2297508 with T2DM prevalence and plasma adiponectin. SREBP-1c has been implicated in the regulation of adiponectin gene expression. Our results therefore raise the possibility that sequence variations at the SREBF-1 gene locus might contribute to T2DM risk, at least in part, by altering circulating adiponectin levels.
- Subjects :
- Male
medicine.medical_specialty
Genotype
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Population
Medicine (miscellaneous)
Single-nucleotide polymorphism
Type 2 diabetes
Biology
Polymorphism, Single Nucleotide
Body Mass Index
Insulin resistance
Risk Factors
Internal medicine
Prevalence
medicine
Humans
Genetic Predisposition to Disease
education
Aged
education.field_of_study
Nutrition and Dietetics
Adiponectin
Case-control study
Genetic Variation
nutritional and metabolic diseases
Middle Aged
medicine.disease
Obesity
Endocrinology
Diabetes Mellitus, Type 2
Austria
Case-Control Studies
Female
Insulin Resistance
Sterol Regulatory Element Binding Protein 1
Body mass index
Subjects
Details
- ISSN :
- 14765497 and 03070565
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- International Journal of Obesity
- Accession number :
- edsair.doi.dedup.....fcb25a8fa462c59bfe7683b65557e3f3