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Hearing Thresholds and fMRI of Auditory Cortex Following Eighth Cranial Nerve Surgery
- Source :
- Otolaryngology–Head and Neck Surgery. 149:492-499
- Publication Year :
- 2013
- Publisher :
- Wiley, 2013.
-
Abstract
- Determine whether auditory cortex (AC) organization changed following eighth cranial nerve surgery in adults with vestibular-cochlear nerve pathologies. We examined whether hearing thresholds before and after surgery correlated with increased ipsilateral activation of AC from the intact ear.During magnetic resonance imaging sessions before and 3 and 6 months after surgery, subjects listened with the intact ear to noise-like random spectrogram sounds.Departments of Radiology and Otolaryngology of Washington University School of Medicine.Three patients with acoustic neuromas received Gamma Knife radiosurgery (GK); 1 patient with Meniere's disease and 5 with acoustic neuromas had surgical resections (SR); 2 of the latter also had GK. Hearing thresholds in each ear were for pure tone stimuli from 250 to 8000 Hz before and after surgery (3 and 6 months). At the same intervals, we imaged blood oxygen level-dependent responses to auditory stimulation of the intact ear using an interrupted single-event design.Hearing thresholds in 2 of 3 individuals treated with GK did not change. Five of 6 individuals became unilaterally deaf after SRs. Ipsilateral AC activity was present before surgery in 6 of 9 individuals with ipsilateral spatial extents greater than contralateral in 3 of 9. Greater contralateral predominance was significant especially in left compared to right ear affected individuals, including those treated by GK.Lateralization of auditory-evoked responses in AC did not change significantly after surgery possibly due to preexisting sensory loss before surgery, indicating that less than profound loss may prompt cortical reorganization.
- Subjects :
- Adult
Male
Auditory perception
medicine.medical_specialty
medicine.medical_treatment
Acoustic neuroma
Audiology
Radiosurgery
Auditory cortex
Article
Vestibulocochlear nerve
otorhinolaryngologic diseases
medicine
Humans
Meniere Disease
Auditory Cortex
medicine.diagnostic_test
Echo-Planar Imaging
business.industry
Magnetic resonance imaging
Neuroma, Acoustic
Middle Aged
Vestibulocochlear Nerve
medicine.disease
Magnetic Resonance Imaging
Surgery
Treatment Outcome
Acoustic Stimulation
Otorhinolaryngology
Auditory Perception
Audiometry, Pure-Tone
Female
sense organs
Unilateral hearing loss
business
Subjects
Details
- ISSN :
- 10976817 and 01945998
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- Otolaryngology–Head and Neck Surgery
- Accession number :
- edsair.doi.dedup.....fca7df887b64ed1ec1bed778a3086c44