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Suppression of ERK signalling abolishes primitive endoderm formation but does not promote pluripotency in rabbit embryo
- Source :
- Development (Cambridge, England), Piliszek, A, Madeja, Z E & Plusa, B 2017, ' Suppression of ERK signalling abolishes primitive endoderm formation but does not promote pluripotency in rabbit embryo ', Development, vol. 144, pp. 3719-3730 . https://doi.org/10.1242/dev.156406
- Publication Year :
- 2017
- Publisher :
- The Company of Biologists, 2017.
-
Abstract
- Formation of epiblast (EPI) – the founder line of all embryonic lineages – and extra-embryonic supportive tissues is one of the key events in mammalian development. The prevailing model of early mammalian development is based almost exclusively on the mouse. Here, we provide a comprehensive, stage-by-stage analysis of EPI and extra-embryonic primitive endoderm (PrE) formation during preimplantation development of the rabbit. Although we observed that rabbit embryos have several features in common with mouse embryos, including a stage-related initiation of lineage specification, our results demonstrate the existence of some key differences in lineage specification among mammals. Contrary to the current view, our data suggest that reciprocal repression of GATA6 and NANOG is not fundamental for the initial stages of PrE versus EPI specification in mammals. Furthermore, our results provide insight into the observed discrepancies relating to the role of FGF/ERK signalling in PrE versus EPI specification between mouse and other mammals.<br />Highlighted Article: A comprehensive analysis of rabbit preimplantation development reveals key differences between rabbit and mouse, with some aspects of lineage specification in rabbit more closely resembling that of human and primate embryos.
- Subjects :
- 0301 basic medicine
Homeobox protein NANOG
MAP Kinase Signaling System
Cellular differentiation
Rabbit
Germ layer
Biology
Mice
03 medical and health sciences
0302 clinical medicine
GATA6 Transcription Factor
HMGB Proteins
parasitic diseases
SOXF Transcription Factors
medicine
FGF
Animals
Cell Lineage
Extracellular Signal-Regulated MAP Kinases
Molecular Biology
Genetics
Epiblast
Gene Expression Profiling
SOXB1 Transcription Factors
Endoderm
Gene Expression Regulation, Developmental
Nanog Homeobox Protein
Cell Differentiation
Embryo
Embryonic stem cell
Cell biology
Blastocyst
030104 developmental biology
medicine.anatomical_structure
Female
Rabbits
Primitive endoderm
Germ Layers
030217 neurology & neurosurgery
Research Article
Developmental Biology
Subjects
Details
- ISSN :
- 14779129 and 09501991
- Database :
- OpenAIRE
- Journal :
- Development
- Accession number :
- edsair.doi.dedup.....fca5d4f794c104def5777b40a67471df