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Recent Updates on the Synthesis of Bioactive Quinoxaline-Containing Sulfonamides
- Source :
- Applied Sciences, Vol 11, Iss 5702, p 5702 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Quinoxaline is a privileged pharmacophore that has broad-spectrum applications in the fields of medicine, pharmacology and pharmaceutics. Similarly, the sulfonamide moiety is of considerable interest in medicinal chemistry, as it exhibits a wide range of pharmacological activities. Therefore, the therapeutic potential and biomedical applications of quinoxalines have been enhanced by incorporation of the sulfonamide group into their chemical framework. The present review surveyed the literature on the preparation, biological activities and structure-activity relationship (SAR) of quinoxaline sulfonamide derivatives due to their broad range of biomedical activities, such as diuretic, antibacterial, antifungal, neuropharmacological, antileishmanial, anti-inflammatory, anti-tumor and anticancer action. The current biological diagnostic findings in this literature review suggest that quinoxaline-linked sulfonamide hybrids are capable of being established as lead compounds; modifications on quinoxaline sulfonamide derivatives may give rise to advanced therapeutic agents against a wide variety of diseases.
- Subjects :
- Antifungal
Technology
synthesis
medicine.drug_class
QH301-705.5
QC1-999
anticancer
01 natural sciences
chemistry.chemical_compound
Quinoxaline
quinoxaline sulfonamides
medicine
Moiety
General Materials Science
Biology (General)
Instrumentation
QD1-999
anti-inflammatory
Fluid Flow and Transfer Processes
chemistry.chemical_classification
010405 organic chemistry
Process Chemistry and Technology
Physics
General Engineering
Antimicrobial
Engineering (General). Civil engineering (General)
Combinatorial chemistry
0104 chemical sciences
Computer Science Applications
Sulfonamide
010404 medicinal & biomolecular chemistry
Chemistry
chemistry
Pharmaceutics
antimicrobial
Pharmacophore
TA1-2040
Subjects
Details
- Language :
- English
- ISSN :
- 20763417
- Volume :
- 11
- Issue :
- 5702
- Database :
- OpenAIRE
- Journal :
- Applied Sciences
- Accession number :
- edsair.doi.dedup.....fc9b3f16f4ec5fc8a08782a5193a77d4