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Treatment with rituximab affects both the cellular and the humoral arm of the immune system in patients with SLE
- Source :
- Clinical Immunology. 122:62-74
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Herein we investigated how rituximab-induced B cell depletion affected leukocyte subpopulations and antibody titers in SLE patients. We focused our analysis on time points related to absence and return of B cells after depletion. A correlation was found between the baseline frequency and time to repopulation; the fewer B cells initially, the longer to their return. While the few B cells remaining after treatment were of memory, double-negative (IgD-CD27-), and CD5+ phenotype, the returning B cells were mainly naïve, indicating de novo production of B cells. Serum levels of IgG and antibodies against Ro52, Ro60, La44, measles and tetanus remained unchanged, while decreases in IgM, IgE, anti-dsDNA and anti-C1q antibodies were observed. Additionally, a significant increase in activated CD4+ and CD8+ T cells, as well as CD25bright FOXP3+ regulatory T cells was observed. In conclusion, both the humoral and the cellular immune systems were affected by treatment with rituximab.
- Subjects :
- medicine.medical_specialty
T-Lymphocytes
Lymphocyte
Immunology
Immunoglobulins
Enzyme-Linked Immunosorbent Assay
Immunoglobulin E
Lymphocyte Depletion
Antibodies, Monoclonal, Murine-Derived
Immune system
immune system diseases
Internal medicine
medicine
Humans
Immunologic Factors
Lupus Erythematosus, Systemic
Immunology and Allergy
Autoantibodies
B-Lymphocytes
Immunity, Cellular
biology
business.industry
Antibodies, Monoclonal
FOXP3
Flow Cytometry
B-1 cell
Endocrinology
medicine.anatomical_structure
Antibody Formation
biology.protein
Female
Rituximab
CD5
Antibody
business
medicine.drug
Subjects
Details
- ISSN :
- 15216616
- Volume :
- 122
- Database :
- OpenAIRE
- Journal :
- Clinical Immunology
- Accession number :
- edsair.doi.dedup.....fc900e18c6feb4e88fa237ad5f7bcb4d