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Homograft Rabbit Skin Protection by Phenothiazine Derivatives

Authors :
Richard C. Lillehei
Charles H. Mayo
Warren J. Warwick
Zwi Eyal
Source :
Science. 148:1468-1469
Publication Year :
1965
Publisher :
American Association for the Advancement of Science (AAAS), 1965.

Abstract

Rejection of homografts of rabbit skin can be delayed by treatment with either chlorpromazine, perphenazine, or promethazine. Promethazine can also delay rejection of second-set homografts. The membrane protective action of these phenothiazine derivatives appears to be the most likely mechanism of this activity.

Subjects

Subjects :
Skin protection
Perphenazine
Multidisciplinary
Chemistry
Stereochemistry
fungi
food and beverages
Rabbit (nuclear engineering)
Pharmacology
Promethazine
body regions
chemistry.chemical_compound
surgical procedures, operative
Phenothiazine
medicine
Chlorpromazine
medicine.drug

Details

ISSN :
10959203 and 00368075
Volume :
148
Database :
OpenAIRE
Journal :
Science
Accession number :
edsair.doi.dedup.....fc8d2e8a34a331ca8290247a8c63262a
Full Text :
https://doi.org/10.1126/science.148.3676.1468
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