Back to Search
Start Over
Cattle tick vaccines: Many candidate antigens, but will a commercially viable product emerge?
- Source :
- International Journal for Parasitology. 42:421-427
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- The cattle tick, Rhipicephalus microplus, is arguably the world's most economically important external parasite of cattle. Sustainable cattle tick control strategies are required to maximise the productivity of cattle in both large production operations and small family farms. Commercially available synthetic acaricides are commonly used in control and eradication programs, but indiscriminate practices in their application have resulted in the rapid evolution of resistance among populations in tropical and subtropical regions where the invasive R. microplus thrives. The need for novel technologies that could be used alone or in combination with commercially available synthetic acaricides is driving a resurgence of cattle tick vaccine discovery research efforts by various groups globally. The aim is to deliver a next-generation vaccine that has an improved efficacy profile over the existing Bm86-based cattle tick vaccine product. We present a short review of these projects and offer our opinion on what constitutes a good target antigen and vaccine, and what might influence the market success of candidate vaccines. The previous experience with Bm86-based vaccines offers perspective on marketing and producer acceptance aspects that a next-generation cattle tick vaccine product must meet for successful commercialisation.
- Subjects :
- Vaccines
biology
Acaricide
business.industry
Cattle Diseases
Tick
biology.organism_classification
Arthropod Proteins
Tick Infestations
Biotechnology
Product (business)
Infectious Diseases
Vaccine product
Protective antigen
parasitic diseases
Rhipicephalus
Animals
Rhipicephalus microplus
Cattle
Parasitology
Tick Control
Antigens
business
Target antigen
Subjects
Details
- ISSN :
- 00207519
- Volume :
- 42
- Database :
- OpenAIRE
- Journal :
- International Journal for Parasitology
- Accession number :
- edsair.doi.dedup.....fc8734d7fdee0c3e30e29b1cb61004de