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Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer
- Source :
- International journal of cancer. Journal international du cancer, 148(2), 307-319. Wiley-Liss Inc., Int J Cancer, Kho, P, Amant, F, Annibali, D, Ashton, K, Attia, J, Auer, P L, Beckmann, M W, Black, A, Brinton, L, Buchanan, D D, Chanock, S J, Chen, C, Chen, M M, Cheng, T H T, Cook, L S, Crous-bous, M, Czene, K, De Vivo, I, Dennis, J, Dörk, T, Dowdy, S C, Dunning, A M, Dürst, M, Easton, D F, Ekici, A B, Fasching, P A, Fridley, B L, Friedenreich, C M, García-closas, M, Gaudet, M M, Giles, G G, Goode, E L, Gorman, M, Haiman, C A, Hall, P, Hankinson, S E, Hein, A, Hillemanns, P, Hodgson, S, Hoivik, E A, Holliday, E G, Hunter, D J, Jones, A, Kraft, P, Krakstad, C, Lambrechts, D, Le Marchand, L, Liang, X, Lindblom, A, Lissowska, J, Long, J, Lu, L, Magliocco, A M, Martin, L, Mcevoy, M, Milne, R L, Mints, M, Nassir, R, Otton, G, Palles, C, Pooler, L, Proietto, T, Rebbeck, T R, Renner, S P, Risch, H A, Rübner, M, Runnebaum, I, Sacerdote, C, Sarto, G E, Schumacher, F, Scott, R J, Setiawan, V W, Shah, M, Sheng, X, Shu, X, Southey, M C, Tham, E, Tomlinson, I, Trovik, J, Turman, C, Tyrer, J P, Van Den Berg, D, Wang, Z, Wentzensen, N, Xia, L, Xiang, Y, Yang, H P, Yu, H, Zheng, W, Webb, P M, Thompson, D J, Spurdle, A B, Glubb, D M & O'mara, T A 2020, ' Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer ', Cancer Epidemiology . https://doi.org/10.1002/ijc.33206
- Publication Year :
- 2021
- Publisher :
- WILEY, 2021.
-
Abstract
- Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectional, two-sample Mendelian randomization analysis to investigate the relationship between levels of three blood lipids (low-density lipoprotein [LDL] and high-density lipoprotein [HDL] cholesterol, and triglycerides) and endometrial cancer risk. Genetic variants associated with each of these blood lipid levels (P
- Subjects :
- Oncology
Cancer Research
Colorectal cancer
Blood lipids
chemistry.chemical_compound
0302 clinical medicine
HDL cholesterol
Medicine
triglycerides
METABOLIC SYNDROME
2. Zero hunger
Mendelian Randomization Analysis
ASSOCIATION
3. Good health
030220 oncology & carcinogenesis
LDL cholesterol
SERUM-LIPIDS
Female
lipids (amino acids, peptides, and proteins)
Life Sciences & Biomedicine
Risk
medicine.medical_specialty
endometrial cancer risk
Article
03 medical and health sciences
INFLAMMATION
Internal medicine
Mendelian randomization
CAUSAL
Humans
Science & Technology
Cholesterol
business.industry
Endometrial cancer
Cholesterol, HDL
Case-control study
Cholesterol, LDL
medicine.disease
Endometrial Neoplasms
BODY-MASS INDEX
LIPOPROTEIN
chemistry
Case-Control Studies
RISK-FACTORS
Metabolic syndrome
business
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 00207136
- Database :
- OpenAIRE
- Journal :
- International journal of cancer. Journal international du cancer, 148(2), 307-319. Wiley-Liss Inc., Int J Cancer, Kho, P, Amant, F, Annibali, D, Ashton, K, Attia, J, Auer, P L, Beckmann, M W, Black, A, Brinton, L, Buchanan, D D, Chanock, S J, Chen, C, Chen, M M, Cheng, T H T, Cook, L S, Crous-bous, M, Czene, K, De Vivo, I, Dennis, J, Dörk, T, Dowdy, S C, Dunning, A M, Dürst, M, Easton, D F, Ekici, A B, Fasching, P A, Fridley, B L, Friedenreich, C M, García-closas, M, Gaudet, M M, Giles, G G, Goode, E L, Gorman, M, Haiman, C A, Hall, P, Hankinson, S E, Hein, A, Hillemanns, P, Hodgson, S, Hoivik, E A, Holliday, E G, Hunter, D J, Jones, A, Kraft, P, Krakstad, C, Lambrechts, D, Le Marchand, L, Liang, X, Lindblom, A, Lissowska, J, Long, J, Lu, L, Magliocco, A M, Martin, L, Mcevoy, M, Milne, R L, Mints, M, Nassir, R, Otton, G, Palles, C, Pooler, L, Proietto, T, Rebbeck, T R, Renner, S P, Risch, H A, Rübner, M, Runnebaum, I, Sacerdote, C, Sarto, G E, Schumacher, F, Scott, R J, Setiawan, V W, Shah, M, Sheng, X, Shu, X, Southey, M C, Tham, E, Tomlinson, I, Trovik, J, Turman, C, Tyrer, J P, Van Den Berg, D, Wang, Z, Wentzensen, N, Xia, L, Xiang, Y, Yang, H P, Yu, H, Zheng, W, Webb, P M, Thompson, D J, Spurdle, A B, Glubb, D M & O'mara, T A 2020, ' Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer ', Cancer Epidemiology . https://doi.org/10.1002/ijc.33206
- Accession number :
- edsair.doi.dedup.....fc820ed3566869016ef8bb4b7246bef2