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Is grand multiparity associated with an increased risk of dysglycaemia?
- Source :
- Diabetologia. 49(7)
- Publication Year :
- 2005
-
Abstract
- We sought to determine the risk of diabetes and IGT/IFG with grand multiparity.Women, agedor =25 years, from the Australian Diabetes, Obesity and Lifestyle Study and the Crossroads Undiagnosed Disease Study (a rural study in Victoria, Australia), participated in a household census (response 67 and 70%, respectively), subsequently attending a biomedical examination that included an oral glucose tolerance test (58% [6198] and 69% [819]).After adjusting for age, obesity and socio-economic status, diabetes, but not IGT/IFG, was less common among women with a parity of 1 to 2 (odds ratio [OR]=0.64 [0.48-0.84]) and 3 to 4 (OR=0.72 [0.53-0.96]) than in grand multiparous women. This relationship was unrelated to past hysterectomy, use of the oral contraceptive pill or menopausal status.Grand multiparity is associated with an increased risk of diabetes but not of IGT/IFG. We postulate that parity accelerates transition from IGT/IFG to diabetes, more than it does transition from normal glucose tolerance to IGT/IFG.
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
genetic structures
endocrine system diseases
Endocrinology, Diabetes and Metabolism
education
Hysterectomy
Random Allocation
Pregnancy
Risk Factors
Diabetes mellitus
Surveys and Questionnaires
Glucose Intolerance
Internal Medicine
medicine
Contraceptive Agents, Female
Diabetes Mellitus
Humans
Risk factor
Aged
Gynecology
Aged, 80 and over
Grand multiparity
business.industry
Australia
nutritional and metabolic diseases
Human physiology
Glucose Tolerance Test
Middle Aged
medicine.disease
Health Surveys
Postmenopause
Diabetes, Gestational
Parity
Increased risk
Case-Control Studies
Female
business
hormones, hormone substitutes, and hormone antagonists
Demography
Subjects
Details
- ISSN :
- 0012186X
- Volume :
- 49
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....fc813c52b3de47db77749e767e43b348