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5 -HT1A Receptor agonist (8-OH-DPAT) and 5-HT2 receptor agonist (DOI) disrupt the non-cognitive performance of rats in a working memory task
- Source :
- Journal of Psychopharmacology. 12:177-185
- Publication Year :
- 1998
- Publisher :
- SAGE Publications, 1998.
-
Abstract
- The present study investigated the role of 5-HT1A and 5-HT2 receptors in the execution of a working memory task (delayed non-matching to position, DNMTP) by assessing the influence of 8-OH-DPAT (5-HT1A receptor agonist) and DOI (5-HT 2 receptor agonist) on the performance of rats lesioned with 5,7-dihydroxytryptamine (5,7-DHT) and their controls. Post-mortem neurochemical analysis revealed that serotonin and 5-hydroxyindoleacetic acid levels were reduced in examined brain areas (especially in the hippocampus where there was a 90 percent reduction). Noradrenaline concentrations were also decreased (mostly on the same side of the injection) by about 20 percent. 5,7-DHT lesioned rats did not significantly differ from their controls in performance in the DNMTP task. At the 30 μg/kg dose, 8-OH-DPAT did not affect the DNMTP-performance of rats, but at the higher dose (100 μg/kg) it reduced the probability of responding to the sample lever. DOI (100 and 300 μg/kg) also interfered with the non-cognitive performance of rats. Since neither of these agonists affected significantly the choice accuracy, they do not appear to influence the working memory per se. The 5,7-DHT lesioned rats did not differ from their controls in response to these agonists. These results suggest that the combination of 5-HT1A receptor stimulation by 8-OH-DPAT and 5-HT2 receptor stimulation by DOI can interfere with the non-cognitive performance of rats in the DNMTP task. The results further indicate that the effect of 8-OH-DPAT may be mediated through post-synaptic rather than pre-synaptic 5-HT1A receptors.
- Subjects :
- Male
Agonist
medicine.medical_specialty
medicine.drug_class
Hippocampus
Norepinephrine
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Receptor, Serotonin, 5-HT2C
medicine
Animals
Receptor, Serotonin, 5-HT2A
Pharmacology (medical)
Rats, Wistar
Receptor
5-HT receptor
Pharmacology
8-Hydroxy-2-(di-n-propylamino)tetralin
Dose-Response Relationship, Drug
8-OH-DPAT
5-HT2 receptor
Amphetamines
Brain
Hydroxyindoleacetic Acid
Rats
Serotonin Receptor Agonists
030227 psychiatry
Psychiatry and Mental health
Endocrinology
chemistry
Receptors, Serotonin
Mental Recall
Conditioning, Operant
5-HT1A receptor
Serotonin
Psychology
Receptors, Serotonin, 5-HT1
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14617285 and 02698811
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Journal of Psychopharmacology
- Accession number :
- edsair.doi.dedup.....fc801548ee67eaf270b649123ba9dfcb