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Analysis of Characteristics Microvessel Density of Thyroid Malignant and Benign Nodules on Contrast-Enhanced Ultrasonography
- Source :
- Advanced Ultrasound in Diagnosis and Therapy, Vol 2, Iss 3, Pp 167-172 (2018)
- Publication Year :
- 2018
- Publisher :
- Editorial Office of Advanced Ultrasound in Diagnosis and Therapy, 2018.
-
Abstract
- Objective: To analyze the contrast-enhanced ultrasonography (CEUS) characteristics and microvessel density (MVD) of thyroid carcinomas vs. benign thyroid lesions, and to determine the value of CEUS in the clinical diagnosis of thyroid carcinoma. Methods: Forty-five patients (34 women, 11 men; mean age, 45.95 ± 12.20 years) with 57 thyroid nodules underwent preoperative CEUS with SonoVue (injected as a bolus via an elbow vein). The CEUS data were analyzed using QLAB quantitative analysis software. The enhancement patterns and quantitative parameters of thyroid carcinoma were evaluated.Additionally, immunohistochemistry was performed to evaluate MVD. Results: Most malignant nodules showed hypo-enhancement, and this enhancement pattern had 68.18% sensitivity and 92.31% specificity in diagnosing thyroid carcinomas. Most benign nodules showed ring enhancement, which had 46.15% sensitivity and 100% specificity in diagnosing benign nodules. Compared with the peripheral glandular tissue, thyroid carcinomas had significantly smaller peak intensities (PI) and wash-in slopes (P < 0.05). Malignant nodules had significantly lower MVD than benign nodules (P < 0.05). A positive correlation was between the PI and MVD (P < 0.01). Conclusion: CEUS can improve the diagnosis of thyroid carcinomas, and is a useful complement to conventional ultrasonography.
- Subjects :
- thyroid carcinoma|contrast-enhanced ultrasound|enhancement pattern|microvessel density|immunohistochemistry
Pathology
medicine.medical_specialty
business.industry
media_common.quotation_subject
Thyroid
General Medicine
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine.anatomical_structure
medicine
Medical technology
Contrast (vision)
Medicine
030211 gastroenterology & hepatology
Ultrasonography
R855-855.5
business
Microvessel density
media_common
Subjects
Details
- Language :
- English
- ISSN :
- 25762516
- Volume :
- 2
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Advanced Ultrasound in Diagnosis and Therapy
- Accession number :
- edsair.doi.dedup.....fc7405b5fc7cb9177fb1a1da26b7bf82