Au(I)-Catalyzed Synthesis of Trisubstituted Indolizines from 2-Propargyloxypyridines and Methyl Ketones

Authors :: Leslie A. Nickerson
Evan O. Romero
Jaimie E. Van de Burg
Colin T. Hartgerink
Emily E. Zerull
Matthew D. Rossler
Richard J. Staples
Miles M. Mason
Abigail K. Frndak
Carolyn E. Anderson
Benjamin L. Boss
Source :: Organic letters. 21(14)
Publication Year :: 2019
Abstract: A new Au(I)-catalyzed method for the preparation of trisubstituted indolizines from easily accessible 2-propargyloxy-pyridines is reported. The reaction tolerates a wide range of functionality, allowing for diversity to be introduced in four distinct regions of the product (R, R

Subjects :: 010405 organic chemistry
Chemistry
Organic Chemistry
Physical and Theoretical Chemistry
010402 general chemistry
01 natural sciences
Biochemistry
Combinatorial chemistry
0104 chemical sciences
Catalysis

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