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Myofibrosarcoma of the Breast
- Source :
- The American Journal of Surgical Pathology. 21:489-496
- Publication Year :
- 1997
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 1997.
-
Abstract
- A case of myofibrosarcoma of the breast is described. A 55-year-old woman presented with a small mammary nodule. A large recurrent lesions appeared a month later, and the patient died 11 months following initial presentation from diffuse pleuropulmonary metastases. Histologically, the primary tumor consisted mainly of spindled cells, arranged in fascicles and surrounded by varying quantities of dense hyaline collagen. The recurrent lesion had a more pleomorphic organization. In both lesions, there was positive immunostaining for vimentin, smooth-muscle actin, and fibronectin, and negative results for desmin, laminin, and type IV collagen. Electron microscopy revealed abundant rough endoplasmic reticulum, myofilaments with focal densities, and the fibronexus junctions and fibronectin fibrils characteristic of myofibroblasts. Given these cellular features and behavior, the tumor was interpreted as a malignant neoplasm showing myofibroblastic differentiation, i.e., a myofibrosarcoma. This case enlarges the group of myofibrosarcoma of breast, also with the demonstration of fibronexus and fibronectin fibrils. The paper emphasizes the criteria required for myofibroblastic differentiation and reviews lesions of the breast reported in the literature as myofibroblastic.
- Subjects :
- Pathology
medicine.medical_specialty
Fibrosarcoma
Breast Neoplasms
Vimentin
macromolecular substances
Histogenesis
Pathology and Forensic Medicine
Neoplasms, Muscle Tissue
Type IV collagen
medicine
Humans
Hyaline
biology
Cell Differentiation
Fibroblasts
Middle Aged
medicine.disease
Immunohistochemistry
Primary tumor
Low Grade Myofibroblastic Sarcoma
biology.protein
Female
Surgery
Desmin
Sarcoma
Anatomy
Subjects
Details
- ISSN :
- 01475185
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- The American Journal of Surgical Pathology
- Accession number :
- edsair.doi.dedup.....fc5e2d1f3a176ac420f967f3bb486f4b