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Noninvasive detection of coronary artery wall thickening with age in healthy subjects using high resolution MRI with beat-to-beat respiratory motion correction
- Source :
- Journal of magnetic resonance imaging : JMRI. 34(4)
- Publication Year :
- 2011
-
Abstract
- Purpose: To demonstrate coronary artery wall thickening with age in a small healthy cohort using a highly efficient, reliable, and reproducible high-resolution MR technique. Materials and Methods: A 3D cross-sectional MR vessel wall images (0.7 × 0.7 × 3 mm resolution) with retrospective beat-to-beat respiratory motion correction (B2B-RMC) were obtained in the proximal right coronary artery of 21 healthy subjects (age, 22–62 years) with no known cardiovascular disease. Lumen and outer wall (lumen + vessel wall) areas were measured in one central slice from each subject and average wall thickness and wall area/outer wall area ratio (W/OW) calculated. Results: Imaging was successful in 18 (86%) subjects with average respiratory efficiency 99.3 ± 1.7%. Coronary vessel wall thickness and W/OW significantly correlate with subject age, increasing by 0.088 mm and 0.031 per decade respectively (R = 0.53, P = 0.024 and R = 0.48, P = 0.046). No relationship was found between lumen area and vessel wall thickness (P = NS), but outer wall area increased significantly with vessel wall thickness at 19 mm2 per mm (P = 0.046). This is consistent with outward vessel wall remodeling. Conclusion: Despite the small size of our healthy cohort, using high-resolution MR imaging and B2B-RMC, we have demonstrated increasing coronary vessel wall thickness and W/OW with age. The results obtained are consistent with outward vessel wall remodeling. J. Magn. Reson. Imaging 2011;. © 2011 Wiley-Liss, Inc.
- Subjects :
- Male
Aging
Beat (acoustics)
Coronary Angiography
Respiratory motion correction
Cohort Studies
Motion
Imaging, Three-Dimensional
Reference Values
medicine
Humans
Radiology, Nuclear Medicine and imaging
Respiratory system
medicine.diagnostic_test
business.industry
Respiration
Coronary Stenosis
Magnetic resonance imaging
Anatomy
Coronary Vessels
Coronary arteries
medicine.anatomical_structure
Coronary vessel
Regression Analysis
Female
Nuclear medicine
business
Magnetic Resonance Angiography
Lumen (unit)
Artery
Subjects
Details
- ISSN :
- 15222586
- Volume :
- 34
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Accession number :
- edsair.doi.dedup.....fc5bb223a9d371cb09d5749cd1efe9f4