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Circulating Short-Chain Fatty Acids Are Positively Associated with Adiposity Measures in Chinese Adults
- Source :
- Nutrients, Volume 12, Issue 7, Nutrients, Vol 12, Iss 2127, p 2127 (2020)
- Publication Year :
- 2020
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2020.
-
Abstract
- Epidemiological studies suggest a positive association between obesity and fecal short-chain fatty acids (SCFAs) produced by microbial fermentation of dietary carbohydrates, while animal models suggest increased energy harvest through colonic SCFA production in obesity. However, there is a lack of human population-based studies with dietary intake data, plasma SCFAs, gut microbial, and anthropometric data. In 490 Chinese adults aged 30&ndash<br />68 years, we examined the associations between key plasma SCFAs (butyrate/isobutyrate, isovalerate, and valerate measured by non-targeted plasma metabolomics) with body mass index (BMI) using multivariable-adjusted linear regression. We then assessed whether overweight (BMI &ge<br />24 kg/m2) modified the association between dietary-precursors of SCFAs (insoluble fiber, total carbohydrates, and high-fiber foods) with plasma SCFAs. In a sub-sample (n = 209) with gut metagenome data, we examined the association between gut microbial SCFA-producers with BMI. We found positive associations between butyrate/isobutyrate and BMI (p-value &lt<br />0.05). The associations between insoluble fiber and butyrate/isobutyrate differed by overweight (p-value &lt<br />0.10). There was no statistical evidence for an association between microbial SCFA-producers and BMI. In sum, plasma SCFAs were positively associated with BMI and that the colonic fermentation of fiber may differ for adults with versus without overweight.
- Subjects :
- Dietary Fiber
Male
0301 basic medicine
Overweight
Body Mass Index
chemistry.chemical_compound
0302 clinical medicine
Food science
Adiposity
Waist-to-height ratio
education.field_of_study
Isovalerate
Nutrition and Dietetics
Middle Aged
Female
medicine.symptom
lcsh:Nutrition. Foods and food supply
Dietary Carbohydrates
fiber
Adult
Colon
Population
short-chain fatty acids
030209 endocrinology & metabolism
lcsh:TX341-641
Butyrate
gut metagenome
waist-to-height ratio
Article
03 medical and health sciences
BMI
Asian People
medicine
Humans
education
Exercise
Aged
Waist-Hip Ratio
business.industry
Fatty Acids, Volatile
medicine.disease
Obesity
Diet
Gastrointestinal Microbiome
Cross-Sectional Studies
030104 developmental biology
Socioeconomic Factors
chemistry
Fermentation
business
Body mass index
Food Science
Subjects
Details
- Language :
- English
- ISSN :
- 20726643
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....fc5acbbbf8162b522b9c7619a16f210e
- Full Text :
- https://doi.org/10.3390/nu12072127