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Potential neuroprotective effects of acupuncture stimulation on diabetes mellitus in a global ischemic rat model
- Source :
- Physiological Measurement. 31:633-647
- Publication Year :
- 2010
- Publisher :
- IOP Publishing, 2010.
-
Abstract
- Acupuncture (ACU) is known to be effective in ischemia treatment, and glutamate (GLU) excitotoxicity is an important factor in neuronal cell death. We observed the effect of ACU on cerebral blood flow (%CBF) and DeltaGLU (the changes in GLU release) in the ischemic stroke rat model of diabetic mellitus (DM). A global ischemia was induced using the eleven-vessel occlusion (11-VO) method in 14 Sprague-Dawley rats (DM), which were randomly divided into two groups: the control group and the ACU-treatment group. Extracellular DeltaGLU was assessed using an intra-cerebral biosensor system measuring 256 samples per second, simultaneously with %CBF and electroencephalogram. ACU stimulation was applied to ACU points GB34 and GB39 during the ischemic period. Twenty-three diagnostic parameters were proposed first for a detailed analysis of changes in %CBF and GLU release during ischemia/reperfusion. ACU rats showed a significant decrease in ischemic (p < 0.05) and reperfusion %CBF (p < 0.0001) than control rats, and a significantly larger decrease in ischemic DeltaGLU (p < 0.05) and peak level of reperfusion DeltaGLU (p < 0.005) than control rats. From these results, we suggest that ACU stimulation is responsible for the potential protection of neurons through suppression of %CBF response in the increased plasma osmolality and extracellular DeltaGLU in diabetic rats under ischemic conditions.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
Physiology
Acupuncture Therapy
Biomedical Engineering
Biophysics
Ischemia
Excitotoxicity
Glutamic Acid
Stimulation
medicine.disease_cause
Neuroprotection
Streptozocin
Body Temperature
Brain Ischemia
Diabetes Mellitus, Experimental
Physiology (medical)
Diabetes mellitus
Internal medicine
Animals
Medicine
business.industry
Glutamate receptor
Electroencephalography
medicine.disease
Rats
Plasma osmolality
Disease Models, Animal
Neuroprotective Agents
Endocrinology
Cerebral blood flow
Cerebrovascular Circulation
Anesthesia
Extracellular Space
business
Craniotomy
Neck
Subjects
Details
- ISSN :
- 13616579 and 09673334
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Physiological Measurement
- Accession number :
- edsair.doi.dedup.....fc58dd17f8c7860c184172c7aae6c486