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Effect of octreotide on glucose tolerance in acromegaly
- Source :
- European Journal of Endocrinology. 130:581-586
- Publication Year :
- 1994
- Publisher :
- Oxford University Press (OUP), 1994.
-
Abstract
- Koop BL, Harris AG. Ezzat S. Effect of octreotide on glucose tolerance in acromegaly. Eur J Endocrinol 1994;130:581–6. ISSN 0804–4643 To determine the effect of the somatostatin analog octreotide on glucose tolerance in acromegaly, we examined glucose profiles, oral glucose tolerance and the insulinogenic index in patients treated with this analog. Ninety patients participated in a long-term, prospective, open-label study. There was no significant change between mean daily blood glucose profiles at baseline or during octreotide treatment. Using glucose tolerance test criteria, 61% of 90 patients had normal baseline glucose tolerance. While on octreotide, 20% and 29% of these patients, respectively, developed impaired glucose tolerance or became frankly diabetic. Conversely, three of the patients who were diabetic at baseline (N = 11) became normal (18%) or developed impaired glucose tolerance (9%) during octreotide therapy. There was no relationship between the dose of octreotide and change in glycemic state. The insulinogenic index (insulin/glucose) response to a glucose challenge decreased uniformly in octreotide-treated patients. Female patients and those with elevated baseline insulin levels were more likely to develop diabetes mellitus during octreotide therapy. In conclusion, octreotide significantly alters glucose tolerance in patients with acromegaly, mandating glucose monitoring during this form of therapy. Alan G Harris, Division of Clinical Pharmacology, Department of Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd., Los Angeles, CA 90048, USA
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Octreotide
Diabetes Complications
Impaired glucose tolerance
Endocrinology
Risk Factors
Diabetes mellitus
Internal medicine
Glucose Intolerance
Insulin Secretion
Acromegaly
Diabetes Mellitus
medicine
Humans
Insulin
Prospective Studies
Glycemic
Glucose tolerance test
medicine.diagnostic_test
business.industry
General Medicine
Glucose Tolerance Test
medicine.disease
Circadian Rhythm
Somatostatin
Female
business
medicine.drug
Subjects
Details
- ISSN :
- 1479683X and 08044643
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- European Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....fc577b203549eb7defbfd36ef1de8db3